EVL and C14orf132

		EVL	C14orf132
Description		Enah/Vasp-like	chromosome 14 open reading frame 132
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection	Membrane
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Cerebrospinal fluid AB1-42 levels ( 28247064) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Erectile dysfunction ( 30583798) Mumps ( 28928442)
Interacting Genes		36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		51466	56967
HPRD ID		10942	16603
Ensembl ID		ENSG00000196405	ENSG00000227051
Uniprot IDs		A0A024R6K5 A0A2D1PGY7 Q9UI08	A0A1B0GU51 A0A1B0GWH2 Q9NPU4
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway	Neuron Projection Guidance Axon Guidance Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus T Cell Receptor V(D)J Recombination Post-embryonic Camera-type Eye Development Striatal Medium Spiny Neuron Differentiation Neuron Projection Development Animal Organ Morphogenesis Negative Regulation Of Ruffle Assembly Forebrain Neuron Fate Commitment Hematopoietic Stem Cell Migration Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Negative Regulation Of Thymocyte Apoptotic Process Profilin Binding Thymocyte Apoptotic Process Keratinocyte Development GABAergic Neuron Differentiation Regulation Of Thymocyte Apoptotic Process Positive T Cell Selection Negative Regulation Of Epithelial Cell Migration V(D)J Recombination Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of T Cell Apoptotic Process Regulation Of Ruffle Assembly SWI/SNF Complex T Cell Apoptotic Process T Cell Selection Cell Projection Organization Lymphocyte Apoptotic Process Epithelial Cell Morphogenesis Negative Regulation Of Lymphocyte Apoptotic Process Forebrain Neuron Differentiation Neuron Fate Commitment Regulation Of T Cell Apoptotic Process Positive Regulation Of Actin Filament Polymerization Regulation Of Keratinocyte Proliferation Leukocyte Apoptotic Process Somatic Cell DNA Recombination Thymus Development T Cell Differentiation In Thymus Positive Regulation Of Stress Fiber Assembly Skin Development Actin Polymerization Or Depolymerization Negative Regulation Of Leukocyte Apoptotic Process Protein Homotetramerization Anatomical Structure Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Lymphocyte Apoptotic Process Regulation Of Epithelial Cell Migration
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