PDE4A and PIAS4

Number of citations of the paper that reports this interaction (PMID 20196770)
6

Data Source:
BioGRID (enzymatic study)

		PDE4A	PIAS4
Gene Name		phosphodiesterase 4A, cAMP-specific	protein inhibitor of activated STAT, 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Dipyridamole Iloprost Oxtriphylline Roflumilast Piclamilast Ibudilast Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AIP LYN PIAS4	75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B
Entrez ID		5141	51588
HPRD ID		02527	06910
Ensembl ID		ENSG00000065989
Uniprot IDs		P27815	Q8N2W9
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Immune Response-inhibiting Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tolerance Induction Positive Regulation Of Mast Cell Proliferation Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Metabolic Process Protein Maturation By Protein Folding Histamine Secretion By Mast Cell Positive Regulation Of Protein Sumoylation Regulation Of Signal Transduction Positive Regulation Of Glial Cell Proliferation Regulation Of Monocyte Chemotaxis Positive Regulation Of Apoptotic Process Response To Sterol Depletion Histamine Secretion Positive Regulation Of Programmed Cell Death Regulation Of Platelet Aggregation Regulation Of Protein Kinase A Signaling Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of B Cell Proliferation Histamine Transport Regulation Of B Cell Apoptotic Process Regulation Of Signaling Regulation Of Protein Sumoylation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Metabolic Process Growth Hormone Receptor Signaling Pathway Mast Cell Degranulation Negative Regulation Of Toll-like Receptor Signaling Pathway Protein Sumoylation Regulation Of Mast Cell Degranulation	Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4d phosphodiesterase select splicing xrn2	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4d phosphodiesterase select splicing xrn2	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?