PDE4A

Gene Name		phosphodiesterase 4A, cAMP-specific
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding
	Biological Process	CAMP Catabolic Process Signal Transduction Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Dipyridamole Iloprost Oxtriphylline Roflumilast Piclamilast Ibudilast Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam
Diseases
GWAS
Protein-protein Interactions		3 interactors: AIP LYN PIAS4
Entrez ID		5141
HPRD ID		02527
Ensembl ID		ENSG00000065989
Uniprot IDs		P27815
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Immune Response-inhibiting Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tolerance Induction Positive Regulation Of Mast Cell Proliferation Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Metabolic Process Protein Maturation By Protein Folding Histamine Secretion By Mast Cell Positive Regulation Of Protein Sumoylation Regulation Of Signal Transduction Positive Regulation Of Glial Cell Proliferation Regulation Of Monocyte Chemotaxis Positive Regulation Of Apoptotic Process Response To Sterol Depletion Histamine Secretion Positive Regulation Of Programmed Cell Death Regulation Of Platelet Aggregation Regulation Of Protein Kinase A Signaling Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of B Cell Proliferation Histamine Transport Regulation Of B Cell Apoptotic Process Regulation Of Signaling Regulation Of Protein Sumoylation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Metabolic Process Growth Hormone Receptor Signaling Pathway Mast Cell Degranulation Negative Regulation Of Toll-like Receptor Signaling Pathway Protein Sumoylation Regulation Of Mast Cell Degranulation
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4d phosphodiesterase select splicing xrn2