PDE4A

Description		phosphodiesterase 4A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Cellular Response To Xenobiotic Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)
Novel Interacting Genes		1 novel interacting genes: SMARCA4
Interacting Genes		6 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4
Entrez ID		5141
HPRD ID		02527
Ensembl ID		ENSG00000065989
Uniprot IDs		P27815
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Positive Regulation Of Double-strand Break Repair Negative Regulation Of Cell Growth Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Nucleosome Array Spacer Activity Nuclear Matrix Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Transcription Coregulator Activity GAF Domain Binding Transmembrane Ascorbate Ferrireductase Activity Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Limb Epidermis Development Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Interleukin-5-mediated Signaling Pathway Negative Regulation Of Protein Localization To Chromatin Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Histamine Transport Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Transcription Corepressor Activity Negative Regulation Of Growth Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
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