PDE4A and AIP

Number of citations of the paper that reports this interaction (PubMedID 12810716)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PDE4A	AIP
Description		phosphodiesterase 4A	AHR interacting HSP90 co-chaperone
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aryl Hydrocarbon Receptor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Cellular Response To Xenobiotic Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Positive Regulation Of DNA-templated Transcription Protein Maturation
Pathways		DARPP-32 events G alpha (s) signalling events	Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)	Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4	22 interacting genes: AHR ARNT BTG3 CEBPA CLEC7A CSNK2A1 EGFR ERBB2 GNA13 GNAQ HSP90AA1 HTR6 HUNK IKBKG IRF7 LCOR PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20
Entrez ID		5141	9049
HPRD ID		02527	10408
Ensembl ID		ENSG00000065989	ENSG00000110711
Uniprot IDs		P27815	A0A804HJ38 A0A804HKL7 O00170
PDB IDs		2QYK 3I8V 3TVX	2LKN 4AIF 4APO 7ZUB 8QMO
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Positive Regulation Of Double-strand Break Repair Negative Regulation Of Cell Growth Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Nucleosome Array Spacer Activity Nuclear Matrix Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Transcription Coregulator Activity GAF Domain Binding Transmembrane Ascorbate Ferrireductase Activity Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Limb Epidermis Development Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Interleukin-5-mediated Signaling Pathway Negative Regulation Of Protein Localization To Chromatin Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Histamine Transport Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Transcription Corepressor Activity Negative Regulation Of Growth Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Hsp90 Protein Binding Nuclear Aryl Hydrocarbon Receptor Complex Signal Transduction Intracellular Signal Transduction Embryonic Placenta Development Protein Folding Chaperone Complex Telomerase Holoenzyme Complex Assembly Protein-containing Complex Nuclear Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Positive Regulation Of Catabolic Process Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Guanyl Nucleotide Binding Protein Stabilization Ruffle Membrane Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding ERBB2 Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Unfolded Protein Binding Regulation Of Multicellular Organismal Process Maintenance Of Gastrointestinal Epithelium Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Regulation Of Intracellular Signal Transduction RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation
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