PDE4A and AIP

Number of citations of the paper that reports this interaction (PMID 12810716)
22

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PDE4A	AIP
Gene Name		phosphodiesterase 4A, cAMP-specific	aryl hydrocarbon receptor interacting protein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding	Transcription Coactivator Activity Signal Transducer Activity Protein Binding Transcription Factor Binding GAF Domain Binding Unfolded Protein Binding
	Biological Process	CAMP Catabolic Process Signal Transduction Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Signal Transduction Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Nucleic Acid-templated Transcription
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Dipyridamole Iloprost Oxtriphylline Roflumilast Piclamilast Ibudilast Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AIP LYN PIAS4	16 interactors: AHR ARNT CLEC7A CSNK2A1 EGFR GNA13 GNAQ HSP90AA1 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20
Entrez ID		5141	9049
HPRD ID		02527	10408
Ensembl ID		ENSG00000065989	ENSG00000110711
Uniprot IDs		P27815	O00170
PDB IDs		2QYK 3I8V 3TVX	2LKN 4AIF 4APO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Immune Response-inhibiting Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tolerance Induction Positive Regulation Of Mast Cell Proliferation Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Metabolic Process Protein Maturation By Protein Folding Histamine Secretion By Mast Cell Positive Regulation Of Protein Sumoylation Regulation Of Signal Transduction Positive Regulation Of Glial Cell Proliferation Regulation Of Monocyte Chemotaxis Positive Regulation Of Apoptotic Process Response To Sterol Depletion Histamine Secretion Positive Regulation Of Programmed Cell Death Regulation Of Platelet Aggregation Regulation Of Protein Kinase A Signaling Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of B Cell Proliferation Histamine Transport Regulation Of B Cell Apoptotic Process Regulation Of Signaling Regulation Of Protein Sumoylation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Metabolic Process Growth Hormone Receptor Signaling Pathway Mast Cell Degranulation Negative Regulation Of Toll-like Receptor Signaling Pathway Protein Sumoylation Regulation Of Mast Cell Degranulation	Intracellular Receptor Signaling Pathway Signal Transduction Response To Stress Signaling Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Stimulus Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Protein Refolding Response To External Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Catenin Import Into Nucleus Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Glycolytic Process Regulation Of Cellular Response To Heat Circadian Rhythm Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Gene Expression Negative Regulation Of Cell Death Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Activation Of Phospholipase C Activity Response To Abiotic Stimulus Regulation Of Innate Immune Response Cellular Response To Drug Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Alkanesulfonate Metabolic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4d phosphodiesterase select splicing xrn2	aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4d phosphodiesterase select splicing xrn2	aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp
Tagcloud (Intersection) ?