HAUS7 and CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		HAUS7	CSNK1E
Description		HAUS augmin like complex subunit 7	casein kinase 1 epsilon
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Ciliary Basal Body HAUS Complex Mitotic Spindle Microtubule	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex
	Molecular Function	Protein Binding Thioesterase Binding Microtubule Minus-end Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Centrosome Cycle Regulation Of Microtubule Nucleation Microtubule Organizing Center Organization Spindle Assembly Cell Division	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			Seliciclib Umbralisib
Diseases
GWAS			Keratoconus ( 31855235) Mastocytosis ( 32752121)
Interacting Genes		4 interacting genes: ATF4 CSNK1E DPPA3 UCHL5	61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618
Entrez ID		55559	1454
HPRD ID		18695	02919
Ensembl ID		ENSG00000213397	ENSG00000213923
Uniprot IDs		Q99871	P49674 Q5U045
PDB IDs		7SQK	4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Circadian Rhythm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Programing Of Female Pronucleus GDF15-GFRAL Signaling Pathway ATF4-CREB1 Transcription Factor Complex Negative Regulation Of Translational Initiation In Response To Stress Asparagine Metabolic Process Regulation Of Sodium-dependent Phosphate Transport Regulation Of Proteasomal Protein Catabolic Process Rhythmic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response HRI-mediated Signaling Cellular Response To Leucine Starvation Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Mitochondrial Respirasome Assembly Response To Manganese Ion Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Cellular Response To Manganese Ion General Transcription Initiation Factor Binding Regulation Of Protein Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ino80 Complex Forebrain Morphogenesis Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Male Pronucleus Female Pronucleus Epigenetic Programming In The Zygotic Pronuclei Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Positive Regulation Of Smooth Muscle Cell Apoptotic Process Proteasome Binding Regulation Of DNA Strand Elongation Histone H3K9me2/3 Reader Activity	Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription
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