PARVB and ARHGEF6

Number of citations of the paper that reports this interaction (PMID 12499396)
23

Data Source:
HPRD (two hybrid, in vitro)

		PARVB	ARHGEF6
Gene Name		parvin, beta	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Lamellipodium	Intracellular Cytosol Cell-cell Junction Lamellipodium
	Molecular Function	Actin Binding Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Cell Adhesion Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Reorganization Cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions	Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Non-alcoholic fatty liver disease ( 23535911) Nonalcoholic fatty liver disease ( 22719876)
Protein-Protein Interactions		2 interactors: ARHGEF6 ILK	22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580
Entrez ID		29780	9459
HPRD ID		16284	02226
Ensembl ID		ENSG00000188677	ENSG00000129675
Uniprot IDs		Q9HBI1	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		4EDL 4EDM 4EDN	1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Extracellular Fibril Organization Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Myoblast Differentiation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Projection Organization Myelin Assembly Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Platelet Aggregation Protein Kinase B Signaling Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Myelination In Peripheral Nervous System Lamellipodium Assembly Schwann Cell Development Positive Regulation Of Catalytic Activity Lamellipodium Organization Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Death Positive Regulation Of Cell-matrix Adhesion Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Branching Involved In Ureteric Bud Morphogenesis Schwann Cell Differentiation Regulation Of Intracellular Signal Transduction Ureteric Bud Morphogenesis Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Cell Aging Positive Regulation Of Osteoblast Differentiation Phosphorylation Intracellular Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Cellular Component Assembly Nephron Morphogenesis Regulation Of BMP Signaling Pathway Renal Tubule Morphogenesis JNK Cascade Positive Regulation Of Muscle Cell Differentiation	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction
Tagcloud ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?