PARVB

Description		parvin beta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Actin Binding Protein Binding
	Biological Process	Cell Adhesion Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Monocyte count ( 32888494) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)
Interacting Genes		3 interacting genes: ARHGEF6 ILK PCNT
Entrez ID		29780
HPRD ID		16284
Ensembl ID		ENSG00000188677
Uniprot IDs		A0A087WZB5 Q9HBI1
PDB IDs		4EDL 4EDM 4EDN
Enriched GO Terms of Interacting Partners?		Spindle Organization Mitotic Spindle Organization Cell Projection Organization Microtubule Cytoskeleton Organization Involved In Mitosis Lamellipodium Protein Localization To Cell Cortex Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Plasma Membrane Raft Assembly Schwann Cell Development Microtubule Cytoskeleton Organization Membrane Raft Assembly Plasma Membrane Raft Organization Caveola Assembly Cellular Component Assembly Fibroblast Migration Myelination In Peripheral Nervous System Centrosome Membrane Raft Organization Negative Regulation Of Neural Precursor Cell Proliferation Microtubule Nucleation Branching Involved In Ureteric Bud Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Assembly Tumor Necrosis Factor-mediated Signaling Pathway Nerve Development Intracellular Signaling Cassette Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Outflow Tract Morphogenesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Sarcomere Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Substrate Adhesion-dependent Cell Spreading Microtubule-based Process Positive Regulation Of BMP Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Lamellipodium Assembly Lamellipodium Organization JNK Cascade Glial Cell Development Homotypic Cell-cell Adhesion
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