LIG1 and CDYL

Number of citations of the paper that reports this interaction (PubMedID 33097091)
61

Data Source:
BioGRID (unspecified method)

		LIG1	CDYL
Description		DNA ligase 1	chromodomain Y like
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Chromosome Cytoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Lyase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Crotonyl-CoA Hydratase Activity
	Biological Process	DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair DNA Recombination DNA Damage Response Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Spermatogenesis Spermatid Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome Negative Regulation Of Peptidyl-lysine Crotonylation
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs		Bleomycin
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS			Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 28552196) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Red cell distribution width ( 32888494) Response to ketogenic dietary therapies in epilepsy ( 30009487) Weight ( 28552196)
Interacting Genes		20 interacting genes: CBX3 CDY1 CDYL CDYL2 CEBPA CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1	9 interacting genes: FXR1 H3-4 H3C1 HDAC1 HDAC2 HTRA1 LIG1 REST TTC9C
Entrez ID		3978	9425
HPRD ID		00534	04803
Ensembl ID		ENSG00000105486	ENSG00000153046
Uniprot IDs		A0A8V8TPH8 A0A8V8TQC4 B4DM52 F5GZ28 P18858	Q9Y232
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35 7QNZ 7QO1 7SUM 7SX5 7SXE 8B8T 8VDN 8VDS 8VDT 8VZL 8VZM 9BS3 9BS4	2DNT 2GTR 7N27
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K9me2/3 Reader Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Replication Fork Regulation Of Metabolic Process Chromatin Binding Peptidyl-lysine Dimethylation Epigenetic Regulation Of Gene Expression Response To Dexamethasone Histone H3K27 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K27me3 Reader Activity Histone H3K9 Methyltransferase Activity Nucleoplasm Identical Protein Binding Transcription Corepressor Activity C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Peptidyl-lysine Methylation Negative Regulation Of Gene Expression DNA Strand Elongation Histone H3 Methyltransferase Activity Protein-lysine N-methyltransferase Activity Nuclear Matrix Response To Glucocorticoid Double-strand Break Repair Via Homologous Recombination Brown Fat Cell Differentiation Granulocyte Differentiation Recombinational Repair Negative Regulation Of Transcription By RNA Polymerase II Response To Corticosteroid	Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Stem Cell Population Maintenance Hair Follicle Placode Formation Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Chromatin Remodeling Histone Deacetylase Activity, Hydrolytic Mechanism Host-mediated Suppression Of Viral Transcription Eyelid Development In Camera-type Eye Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Host-mediated Suppression Of Viral Proces NuRD Complex Chromatin Organization Histone Deacetylase Activity Regulation Of Nervous System Development RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Host-mediated Perturbation Of Viral Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Neurogenesis Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Histone Deacetylase Complex Regulation Of Cell Fate Commitment Positive Regulation Of Nervous System Development Heterochromatin Epigenetic Regulation Of Gene Expression Embryonic Digit Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Gliogenesis Transcription Repressor Complex Positive Regulation Of Male Mating Behavior Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation
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