LIG1 and EHMT1

Number of citations of the paper that reports this interaction (PubMedID 28803780)
0

Data Source:
BioGRID (enzymatic study)

		LIG1	EHMT1
Description		DNA ligase 1	euchromatic histone lysine methyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity
	Biological Process	DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair DNA Recombination DNA Damage Response Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Response To Fungicide Positive Regulation Of Cold-induced Thermogenesis Facultative Heterochromatin Formation
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		Bleomycin
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS			Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: CBX3 CDY1 CDYL CDYL2 CEBPA CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1	13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ
Entrez ID		3978	79813
HPRD ID		00534	07383
Ensembl ID		ENSG00000105486	ENSG00000181090
Uniprot IDs		A0A8V8TPH8 A0A8V8TQC4 B4DM52 F5GZ28 P18858	A0A1B0GUD1 A0A1B0GV09 Q9H9B1
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35 7QNZ 7QO1 7SUM 7SX5 7SXE 8B8T 8VDN 8VDS 8VDT 8VZL 8VZM 9BS3 9BS4	2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP 7T7M 8XPT
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K9me2/3 Reader Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Replication Fork Regulation Of Metabolic Process Chromatin Binding Peptidyl-lysine Dimethylation Epigenetic Regulation Of Gene Expression Response To Dexamethasone Histone H3K27 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K27me3 Reader Activity Histone H3K9 Methyltransferase Activity Nucleoplasm Identical Protein Binding Transcription Corepressor Activity C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Peptidyl-lysine Methylation Negative Regulation Of Gene Expression DNA Strand Elongation Histone H3 Methyltransferase Activity Protein-lysine N-methyltransferase Activity Nuclear Matrix Response To Glucocorticoid Double-strand Break Repair Via Homologous Recombination Brown Fat Cell Differentiation Granulocyte Differentiation Recombinational Repair Negative Regulation Of Transcription By RNA Polymerase II Response To Corticosteroid	Epigenetic Regulation Of Gene Expression Nucleoplasm Chromatin Remodeling Transcription Corepressor Binding Pronucleus Chromatin Binding Chromatin Organization Cellular Response To Antibiotic Chromatin Silencing Complex Nucleus ESC/E(Z) Complex Regulation Of Gliogenesis Facultative Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulatory NcRNA-mediated Heterochromatin Formation Genomic Imprinting Nuclear Matrix Heterochromatin Formation Regulation Of RNA Metabolic Process LncRNA Binding Negative Regulation Of Gene Expression, Epigenetic Epigenetic Programming Of Gene Expression Regulation Of Gene Expression Nucleosome Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Antibiotic Regulation Of Glial Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Hepatocyte Homeostasis Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein-cysteine Methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Promoter-specific Chromatin Binding Cellular Response To Trichostatin A Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle DNA Replication, Okazaki Fragment Processing 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity
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