LIG1 and INPP1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		LIG1	INPP1
Name		DNA ligase 1	inositol polyphosphate-1-phosphatase
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Inositol-1,3,4-trisphosphate 1-phosphatase Activity
	Biological Process	DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair DNA Recombination DNA Damage Response Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Synthesis of IP2, IP, and Ins in the cytosol
Drugs		Bleomycin	None
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	None
GWAS		No GWAS studies recorded	Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Machado-Joseph disease (age at onset) ( 32205469 )
Interacting Genes		20 interacting genes: CBX3 CDY1 CDYL CDYL2 CEBPA CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1	11 interacting genes: BBLN BRCA1 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1
Entrez ID		3978	3628
HPRD ID		00534	00923
Ensembl ID		ENSG00000105486	ENSG00000151689
Uniprot IDs		A0A8V8TPH8 A0A8V8TQC4 B4DM52 F5GZ28 P18858	P49441 Q6IBG4
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35 7QNZ 7QO1 7SUM 7SX5 7SXE 8B8T 8VDN 8VDS 8VDT 8VZL 8VZM 9BS3 9BS4	Not available
GO Terms Enriched among Interactors		Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K9me2/3 Reader Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Replication Fork Regulation Of Metabolic Process Chromatin Binding Peptidyl-lysine Dimethylation Epigenetic Regulation Of Gene Expression Response To Dexamethasone Histone H3K27 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K27me3 Reader Activity Histone H3K9 Methyltransferase Activity Nucleoplasm Identical Protein Binding Transcription Corepressor Activity C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Peptidyl-lysine Methylation Negative Regulation Of Gene Expression DNA Strand Elongation Histone H3 Methyltransferase Activity Protein-lysine N-methyltransferase Activity Nuclear Matrix Response To Glucocorticoid Double-strand Break Repair Via Homologous Recombination Brown Fat Cell Differentiation Granulocyte Differentiation Recombinational Repair Negative Regulation Of Transcription By RNA Polymerase II Response To Corticosteroid	DNA Strand Resection Involved In Replication Fork Processing Histone H2AK127 Ubiquitin Ligase Activity DNA Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity Homologous Recombination Cellular Response To Tumor Necrosis Factor Chromosome BRCA1-BARD1 Complex DNA Recombination Okazaki Fragment Processing Involved In Mitotic DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Astrocyte Activation Circadian Temperature Homeostasis Positive Regulation Of Bile Acid Biosynthetic Process G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Subapical Part Of Cell Multinuclear Osteoclast Differentiation BRCA1-B Complex Cell Division Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Type 5 Metabotropic Glutamate Receptor Binding Response To Tumor Necrosis Factor