LIG1

Gene Name		ligase I, DNA, ATP-dependent
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrion Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Anatomical Structure Morphogenesis Telomere Maintenance Via Semi-conservative Replication V(D)J Recombination Response To Hydrogen Peroxide DNA Ligation Involved In DNA Repair Cell Division DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair
Drugs		Bleomycin
Diseases
GWAS
Protein-protein Interactions		6 interactors: CSNK2A1 INPP1 MRE11A PCNA RGS2 TUBB3
Entrez ID		3978
HPRD ID		00534
Ensembl ID		ENSG00000105486
Uniprot IDs		B4DTU4 F5GZ28 P18858
PDB IDs		1X9N
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Base-excision Repair Telomere Maintenance Nucleotide-excision Repair Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Leading Strand Elongation Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Endoreduplication Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Checkpoint Regulation Of Mitotic Recombination Regulation Of Adrenergic Receptor Signaling Pathway DNA Recombination Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity DNA Replication Protein Folding Intra-S DNA Damage Checkpoint Relaxation Of Vascular Smooth Muscle Regulation Of DNA Endoreduplication Relaxation Of Smooth Muscle Telomere Maintenance Via Telomerase Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Translesion Synthesis Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Axon Guidance Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Hydrolase Activity Nucleotide-excision Repair, DNA Gap Filling Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Cell Differentiation Positive Regulation Of Metabolic Process Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Cell Cycle Negative Regulation Of Lipase Activity Postreplication Repair Negative Regulation Of Muscle Contraction
Tagcloud ?		24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 fancg hepg2 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2