LIG1 and CDYL2

Number of citations: 61 (PubMedID 33097091)
Data Source: BioGRID (unspecified method)

		LIG1	CDYL2
Name		DNA ligase 1	chromodomain Y like 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Histone H3K27me3 Reader Activity Histone H3K9me2/3 Reader Activity
	Biological Process	DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair DNA Recombination DNA Damage Response Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Chromatin Organization Negative Regulation Of DNA-templated Transcription
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	None
Drugs		Bleomycin	None
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	None
GWAS		No GWAS studies recorded	Breast cancer ( 23535729 29059683 ) Inflammatory bowel disease ( 27569725 ) Interleukin-10 levels ( 22205395 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Metabolite levels ( 23823483 ) Prostate cancer ( 31748686 ) Pulse pressure ( 30224653 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		20 interacting genes: CBX3 CDY1 CDYL CDYL2 CEBPA CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1	11 interacting genes: DVL3 H3-4 H3C1 HINFP HSF2BP LIG1 LMO3 NXF1 PRMT5 SPANXN2 ZBTB9
Entrez ID		3978	124359
HPRD ID		00534	10819
Ensembl ID		ENSG00000105486	ENSG00000166446
Uniprot IDs		A0A8V8TPH8 A0A8V8TQC4 B4DM52 F5GZ28 P18858	Q8N8U2
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35 7QNZ 7QO1 7SUM 7SX5 7SXE 8B8T 8VDN 8VDS 8VDT 8VZL 8VZM 9BS3 9BS4	2MJ8 4HAE 5JJZ 6V2D 6V2H 6V3N 6V8W 8SP6
GO Terms Enriched among Interactors		Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K9me2/3 Reader Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Replication Fork Regulation Of Metabolic Process Chromatin Binding Peptidyl-lysine Dimethylation Epigenetic Regulation Of Gene Expression Response To Dexamethasone Histone H3K27 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K27me3 Reader Activity Histone H3K9 Methyltransferase Activity Nucleoplasm Identical Protein Binding Transcription Corepressor Activity C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Peptidyl-lysine Methylation Negative Regulation Of Gene Expression DNA Strand Elongation Histone H3 Methyltransferase Activity Protein-lysine N-methyltransferase Activity Nuclear Matrix Response To Glucocorticoid Double-strand Break Repair Via Homologous Recombination Brown Fat Cell Differentiation Granulocyte Differentiation Recombinational Repair Negative Regulation Of Transcription By RNA Polymerase II Response To Corticosteroid	Okazaki Fragment Processing Involved In Mitotic DNA Replication Nucleobase-containing Compound Biosynthetic Process DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing Macromolecule Biosynthetic Process DNA Ligase Activity Chromosome Protein Heterodimerization Activity Structural Constituent Of Chromatin Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nucleosome Assembly Nucleosome Nucleosome Organization Spermatogonial Cell Division Histone H4R3 Methyltransferase Activity Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation