PRKCG and CCHCR1

Number of citations: 0 (PubMedID 16713569)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PRKCG	CCHCR1
Name		protein kinase C gamma	coiled-coil alpha-helical rod protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Cytoplasm Centriole Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding
	Biological Process	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Protein Export From Nucleus Cell Differentiation
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+	None
Drugs		Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib	None
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	None
GWAS		No GWAS studies recorded	Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Feeling nervous ( 29500382 ) Head and neck squamous cell carcinoma ( 32276964 ) Hematology traits ( 23263863 ) Hemoglobin ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Mean spheric corpuscular volume ( 32888494 ) Microalbuminuria ( 31511532 ) Monocyte percentage of white cells ( 32888494 ) Multiple myeloma ( 23955597 ) Nevirapine-induced rash ( 21810746 ) Night sleep phenotypes ( 27126917 ) Prostate cancer ( 21743467 ) Psoriasis ( 30921485 ) Reticulocyte count ( 32888494 ) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 ) Ulcerative colitis ( 28067908 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 21738480 )
Novel Interactors		2 novel interactors: LAIR1 PABPC4	None recorded
Interacting Genes		64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	161 interacting genes: ABI1 ABI2 AIRIM ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CIMIP4 CNN1 CNOT2 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DRC4 DTNB DYDC1 EFHC2 EXOC4 EXOC7 EXOC8 FSD2 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HOOK2 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZRANB1 ZWINT
Entrez ID		5582	54535
HPRD ID		01502	05607
Ensembl ID		ENSG00000126583	ENSG00000204536
Uniprot IDs		A0A804HIU5 B2R5T1 B7Z3W6 P05129	A0A1U9X7G6 B0S7V6 B4DIA2 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31
PDB IDs		2E73 2UZP	Not available
GO Terms Enriched among Interactors		Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity	Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Microtubule-based Process Centrosome Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Organelle Organization Structural Constituent Of Skin Epidermis Centriolar Satellite Keratin Filament Intermediate Filament Structural Molecule Activity Cytoplasm Spindle Pole Cytoskeleton-dependent Intracellular Transport Organelle Localization Microtubule Organizing Center Organization Microtubule Microtubule-based Transport Microtubule Cytoskeleton Organization Cytosol Flemming Body Transport Along Microtubule Microtubule-based Movement Organelle Assembly Protein Localization To Centrosome Identical Protein Binding Microtubule Binding Centrosome Cycle Protein Localization To Cytoskeleton Signaling Adaptor Activity Establishment Of Localization In Cell Intracellular Transport Cell Division Centriole Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell Differentiation Cellular Localization Microtubule Organizing Center Cilium Assembly Ciliary Basal Body Structural Constituent Of Cytoskeleton Establishment Of Organelle Localization Vesicle Tethering Involved In Exocytosis Axonemal A Tubule Inner Sheath Thioesterase Binding Syntaxin Binding