PRKCG and GSK3A

Number of citations of the paper that reports this interaction (PMID 11035810)
124

Data Source:
HPRD (in vivo, in vitro)

		PRKCG	GSK3A
Gene Name		protein kinase C, gamma	glycogen synthase kinase 3 alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Dendrite Perinuclear Region Of Cytoplasm Synaptic Membrane	Cytosol Beta-catenin Destruction Complex
	Molecular Function	Protein Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Zinc Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau-protein Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Learning Or Memory Chemosensory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Pain Rhythmic Process Innervation Negative Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Wnt Signaling Pathway Cell Migration Positive Regulation Of CAMP Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Hypermethylation Of CpG Island Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Transferase Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction Calmodulin induced events WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer XBP1(S) activates chaperone genes Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) IRE1alpha activates chaperones PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Unfolded Protein Response (UPR) Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: ADRBK1 AFAP1 ANXA7 APP ARHGEF25 CASR CCHCR1 CD5 CDC42 CHAT CYTH2 DAB2 DDX58 DVL2 EIF4E EPHB1 EXOC5 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MARK4 NFE2L2 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 STXBP1 TIAM1 TOP2A TRIM5 VTN YWHAB YWHAE YWHAG	31 interactors: AKT1 BCL3 BICD1 CREB1 CREM DEAF1 EBNA1BP2 EIF2B5 FAM193B GLI3 GSKIP HSF1 LRSAM1 MAPT MCL1 MYC NBR1 PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PXN SGK1 SGK3 SPG21 YWHAG
Entrez ID		5582	2931
HPRD ID		01502	06002
Ensembl ID		ENSG00000126583	ENSG00000105723
Uniprot IDs		F5H5C4 P05129	P49840
PDB IDs		2E73 2UZP	2DFM
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Cellular Process Signaling Nervous System Development Cell Communication Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Developmental Process Anatomical Structure Development Generation Of Neurons System Development Neuron Development Neuron Projection Development Neurogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Component Organization Cell Differentiation Response To Stimulus Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Regulation Of Signal Transduction Cell Projection Organization Cellular Response To Stimulus Axon Development Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cell-cell Signaling Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Cell Projection Morphogenesis Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Part Morphogenesis Ephrin Receptor Signaling Pathway Regulation Of Cellular Localization Cell Morphogenesis Regulation Of Synaptic Plasticity Axon Guidance Positive Regulation Of Catalytic Activity Neuron-neuron Synaptic Transmission Transport Regulation Of Cell Development	Response To Stress Protein Phosphorylation Regulation Of Phospholipase Activity Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Platelet Activation Cell Death Death Positive Regulation Of Phospholipase Activity Cell Activation Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Intracellular Signal Transduction Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Apoptotic Process Activation Of Phospholipase C Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Negative Regulation Of Cell Death Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Organonitrogen Compound Developmental Process Response To Growth Factor Phosphate-containing Compound Metabolic Process Wound Healing Regulation Of Cellular Response To Insulin Stimulus Blood Coagulation Hemostasis Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1	2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1	2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste
Tagcloud (Intersection) ?