PRKCG and GABRA1

Number of citations of the paper that reports this interaction (PubMedID 12091471)
0

Data Source:
HPRD (in vivo)

		PRKCG	GABRA1
Description		protein kinase C gamma	gamma-aminobutyric acid type A receptor subunit alpha1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA Receptor Complex GABA-A Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib	Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Topiramate Etomidate Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Picrotoxin Methohexital Chlordiazepoxide Chlordiazepoxide Amoxapine Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Progabide Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Zaleplon Methoxyflurane Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Methyprylon Thiamylal Halothane Halothane Phenobarbital Desflurane Zopiclone Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Clomethiazole Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872) Gait speed in old age ( 28077804)
Interacting Genes		64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	6 interacting genes: DRD4 P2RX2 PPP3CA PRKCD PRKCG UBQLN1
Entrez ID		5582	2554
HPRD ID		01502	00662
Ensembl ID		ENSG00000126583	ENSG00000022355
Uniprot IDs		A0A804HIU5 B2R5T1 B7Z3W6 P05129	A8K177 P14867
PDB IDs		2E73 2UZP	6CDU 6D1S 6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7PBD 7PBZ 7PC0 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG 9H9E
Enriched GO Terms of Interacting Partners?		Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity	Regulation Of Transport Multicellular Organismal Response To Stress Regulation Of Postsynaptic Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Angiotensin Skeletal Muscle Fiber Development Regulation Of Calcium Ion Transport Myotube Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Cell Communication Positive Regulation Of Transport Response To Stress Positive Regulation Of Signaling Regulation Of Endocytosis Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Excitatory Postsynaptic Potential Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Negative Regulation Of Angiotensin-activated Signaling Pathway Enzyme Binding Striated Muscle Cell Development Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Methionine Adenosyltransferase Regulator Activity Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Neurotransmitter Secretion Regulation Of Membrane Potential Regulation Of Calcium-mediated Signaling Muscle Cell Development Positive Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sphingomyelin Catabolic Process Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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