PRKCG and EPHB1

Number of citations of the paper that reports this interaction (PMID 20395553)
5

Data Source:
BioGRID (pull down)

		PRKCG	EPHB1
Gene Name		protein kinase C, gamma	EPH receptor B1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Dendrite Perinuclear Region Of Cytoplasm Synaptic Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Early Endosome Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Zinc Ion Binding	Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Learning Or Memory Chemosensory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Pain Rhythmic Process Innervation Negative Regulation Of Proteasomal Protein Catabolic Process	Angiogenesis Axon Guidance Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction Calmodulin induced events WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		58 interactors: ADRBK1 AFAP1 ANXA7 APP ARHGEF25 CASR CCHCR1 CD5 CDC42 CHAT CYTH2 DAB2 DDX58 DVL2 EIF4E EPHB1 EXOC5 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MARK4 NFE2L2 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 STXBP1 TIAM1 TOP2A TRIM5 VTN YWHAB YWHAE YWHAG	11 interactors: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 GRB10 GRB2 NCK1 PRKCG PXN
Entrez ID		5582	2047
HPRD ID		01502	02790
Ensembl ID		ENSG00000126583	ENSG00000154928
Uniprot IDs		F5H5C4 P05129	P54762
PDB IDs		2E73 2UZP	2DJS 2EAO
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Cellular Process Signaling Nervous System Development Cell Communication Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Developmental Process Anatomical Structure Development Generation Of Neurons System Development Neuron Development Neuron Projection Development Neurogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Component Organization Cell Differentiation Response To Stimulus Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Regulation Of Signal Transduction Cell Projection Organization Cellular Response To Stimulus Axon Development Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cell-cell Signaling Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Cell Projection Morphogenesis Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Part Morphogenesis Ephrin Receptor Signaling Pathway Regulation Of Cellular Localization Cell Morphogenesis Regulation Of Synaptic Plasticity Axon Guidance Positive Regulation Of Catalytic Activity Neuron-neuron Synaptic Transmission Transport Regulation Of Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Morphogenesis Neuron Projection Morphogenesis Cell Projection Organization Neuron Projection Development Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Neuron Development Neuron Differentiation Cell Development Locomotion Nervous System Development Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Signal Transduction Response To External Stimulus Regulation Of Cell Adhesion Signaling Cell Communication Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Signal Complex Assembly Multicellular Organismal Development Cell Differentiation Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Anatomical Structure Development Cell Motility Cell-cell Signaling Positive Regulation Of Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Developmental Process System Development Positive Regulation Of T Cell Activation Cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Signal Transduction
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1	anlage b3 cascades cortical cue endogenously entering ephrin fak gives interneurons migrate migrating misrouted path pfak poa preoptic psrc repulsion repulsive reverse stop str striatal striatum superficial terminate
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1	anlage b3 cascades cortical cue endogenously entering ephrin fak gives interneurons migrate migrating misrouted path pfak poa preoptic psrc repulsion repulsive reverse stop str striatal striatum superficial terminate
Tagcloud (Intersection) ?