PLCB3 and PRKG2

Number of citations: 0 (PubMedID 11278298)
Data Source: HPRD (in vivo)

		PLCB3	PRKG2
Name		phospholipase C beta 3	protein kinase cGMP-dependent 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway	Protein Phosphorylation Signal Transduction Positive Regulation Of Chondrocyte Differentiation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Chloride Transport
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs		None	Fostamatinib
GWAS		Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Vitiligo ( 27723757 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )	Blood pressure (smoking interaction) ( 25189868 ) Body size at age 10 ( 32376654 ) Height ( 19343178 31562340 28552196 18391951 33713608 25282103 23563607 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) HIV-1 susceptibility ( 22174851 ) Pubertal anthropometrics ( 23449627 ) Refractive error ( 32231278 ) Schizophrenia ( 33169155 ) Sleep duration (short sleep) ( 30846698 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7	8 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS RAB11B WDR77
Entrez ID		5331	5593
HPRD ID		02577	09034
Ensembl ID		ENSG00000149782	ENSG00000138669
Uniprot IDs		Q01970	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs		4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO	5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
GO Terms Enriched among Interactors		Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation	Cadherin Binding Monoatomic Ion Transport Postsynaptic Cytosol Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process 6-pyruvoyltetrahydropterin Synthase Activity Oocyte Axis Specification Actin Binding Cytoplasm Regulation Of Monoatomic Ion Transport Myosin Light Chain Kinase Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Phosphothreonine Residue Binding Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Cortex Aorta Smooth Muscle Tissue Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Metal Ion Transport Beta-2 Adrenergic Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Tetrahydrobiopterin Biosynthetic Process Constitutive Secretory Pathway Amyloid-beta Clearance By Transcytosis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cul4B-RING E3 Ubiquitin Ligase Complex Monoatomic Ion Transmembrane Transporter Activity Protein Modification Process Tonic Smooth Muscle Contraction Hypotonic Response Cellular Hypotonic Response Calmodulin Binding Bleb Assembly Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway