PLCB3 and TRPC3

Number of citations of the paper that reports this interaction (PMID 15623527)
19

Data Source:
HPRD (in vivo)

		PLCB3	TRPC3
Gene Name		phospholipase C, beta 3 (phosphatidylinositol-specific)	transient receptor potential cation channel, subfamily C, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		5331	7222
HPRD ID		02577	15999
Ensembl ID		ENSG00000149782	ENSG00000138741
Uniprot IDs		Q01970	J3QTB0 Q13507
PDB IDs		3OHM 4GNK
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?