PLCB3

Name	phospholipase C beta 3
Structure
Interactors	13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
GWAS	Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Vitiligo ( 27723757 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )
Entrez ID	5331
HPRD ID	02577
Ensembl ID	ENSG00000149782
Uniprot IDs	Q01970
PDB IDs	4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO
GO Terms Enriched among Interactors ?	Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation