PLCB3 and CAMK2G

Number of citations: 0 (PubMedID 11325525)
Data Source: HPRD (in vitro, in vivo)

		PLCB3	CAMK2G
Name		phospholipase C beta 3	calcium/calmodulin dependent protein kinase II gamma
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		None	Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
GWAS		Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Vitiligo ( 27723757 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )	Body size at age 10 ( 32376654 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 ) FEV1 ( 30804560 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Multiple sclerosis ( 31604244 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Peak expiratory flow ( 30804560 ) Psoriasis ( 25939698 ) Psoriasis vulgaris ( 26626624 ) Systemic lupus erythematosus ( 28714469 ) Type 2 diabetes ( 30054458 )
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7	51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		5331	818
HPRD ID		02577	03672
Ensembl ID		ENSG00000149782	ENSG00000148660
Uniprot IDs		Q01970	A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3
PDB IDs		4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO	2UX0 2V7O
GO Terms Enriched among Interactors		Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation	Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration