COPS7A and COPS8

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vitro)

		COPS7A	COPS8
Description		COP9 signalosome subunit 7A	COP9 signalosome subunit 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Red blood cell count ( 32888494)	Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)
Interacting Genes		20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 UBC USHBP1
Entrez ID		50813	10920
HPRD ID		16736	16737
Ensembl ID		ENSG00000111652	ENSG00000198612
Uniprot IDs		Q9UBW8	Q99627
PDB IDs		4D10 4D18 4WSN	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process PML Body Regulation Of Blood Vessel Endothelial Cell Migration Nucleus Cellular Response To Hypoxia DeNEDDylase Activity Cellular Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Protein Phosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Phosphorylation Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration GTPase Inhibitor Activity Eukaryotic Translation Initiation Factor 3 Complex Type II Interferon-mediated Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Cellular Response To Angiotensin Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Response To Hypoxia Positive Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction By P53 Class Mediator Response To Angiotensin Nucleoplasm Negative Regulation Of Programmed Cell Death Cytoplasm Response To Decreased Oxygen Levels	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Modification Process Cytosol Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding DeNEDDylase Activity Ubiquitin Ligase Complex Scaffold Activity Protein Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of T Cell Apoptotic Process Eukaryotic Translation Initiation Factor 3 Complex Necroptotic Process Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Programmed Necrotic Cell Death T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Cytoplasm Response To Methotrexate Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of T Cell Apoptotic Process Sulfite Oxidase Activity Negative Regulation Of Helicase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1 To G0 Transition Protein Localization To Astral Microtubule Protein-containing Complex Leukocyte Apoptotic Process Translation Initiation Factor Activity Dihydrofolate Reductase Activity Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?