COPS7A and CPEB2

Number of citations: 54 (PubMedID 22157746)
Data Source: BioGRID (two hybrid)

		COPS7A	CPEB2
Name		COP9 signalosome subunit 7A	cytoplasmic polyadenylation element binding protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	Nucleus Cytoplasm Neuron Projection Synapse
	Molecular Function	Protein Binding	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	None
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Red blood cell count ( 32888494 )	Cognitive flexibility ( 30134085 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 33479058 )
Novel Interactors		None recorded	1 novel interactors: CC2D2A
Interacting Genes		20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42
Entrez ID		50813	132864
HPRD ID		16736	16744
Ensembl ID		ENSG00000111652	ENSG00000137449
Uniprot IDs		Q9UBW8	A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1
PDB IDs		4D10 4D18 4WSN	Not available
GO Terms Enriched among Interactors		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process PML Body Regulation Of Blood Vessel Endothelial Cell Migration Nucleus Cellular Response To Hypoxia DeNEDDylase Activity Cellular Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Protein Phosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Phosphorylation Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration GTPase Inhibitor Activity Eukaryotic Translation Initiation Factor 3 Complex Type II Interferon-mediated Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Cellular Response To Angiotensin Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Response To Hypoxia Positive Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction By P53 Class Mediator Response To Angiotensin Nucleoplasm Negative Regulation Of Programmed Cell Death Cytoplasm Response To Decreased Oxygen Levels	None