COPS7A and RAF1

Number of citations of the paper that reports this interaction (PMID 16364241)
3

Data Source:
BioGRID (two hybrid)

		COPS7A	RAF1
Gene Name		COP9 signalosome subunit 7A	Raf-1 proto-oncogene, serine/threonine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm COP9 Signalosome	Nucleus Cytoplasm Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Pseudopodium
	Molecular Function		Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Cullin Deneddylation	MAPK Cascade Activation Of MAPKK Activity Response To Hypoxia Protein Phosphorylation Apoptotic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Heart Development Blood Coagulation Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Negative Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Somatic Stem Cell Maintenance Regulation Of Rho Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility
Pathways			Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling GP1b-IX-V activation signalling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Transmission across Chemical Synapses Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Ion channel transport GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR Stimuli-sensing channels NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs			Sorafenib Regorafenib Dabrafenib
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Cholesterol, total ( 20686565)
Protein-Protein Interactions		21 interactors: COPS2 COPS3 COPS4 COPS5 COPS8 CSNK2A1 CSNK2B CUL1 CUL5 EIF3E GPS1 JUN NFE2L2 PMF1 PPBP PRKD1 PSMD4 PTGS2 RAF1 TOM1L1 TP53	123 interactors: ADCY6 AGTR1 AKT1 AR ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BIRC2 BIRC3 BRAF CCT3 CDC25A CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 ERBB2IP FYCO1 FYN GNB2 GNG4 GRB10 HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 JAK1 JAK2 KRAS KRT18 KRT8 KSR1 KSR2 LCK LRPAP1 MAP2K1 MAP2K2 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MRAS MYBPC1 MYC NEDD4 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRB PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TIMM50 TMEM70 TSC22D3 UBC UBE2D2 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1
Entrez ID		50813	5894
HPRD ID		16736	01265
Ensembl ID		ENSG00000111652	ENSG00000132155
Uniprot IDs		Q567U8 Q9UBW8	B4E0X2 L7RRS6 P04049
PDB IDs			1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Regulation Of Cell Proliferation Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Modification Process Cellular Metabolic Process Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Cell Communication Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Cell Cycle Apoptotic Signaling Pathway Protein Catabolic Process Regulation Of Cellular Process Intracellular Signal Transduction Negative Regulation Of Cell Death Response To Stimulus Mitotic Cell Cycle Process	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Communication Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Response To Fibroblast Growth Factor Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of MAPK Cascade Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Programmed Cell Death Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Apoptotic Process Positive Regulation Of Phosphorylation Cell Death Death Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Innate Immune Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Transferase Activity
Tagcloud ?		abomasum actb b2m blat butterfat calculating coro1b cows dnajc19 eif3k emd gapdh genorm golga5 goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		abomasum actb b2m blat butterfat calculating coro1b cows dnajc19 eif3k emd gapdh genorm golga5 goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?