COPS7A

Name	COP9 signalosome subunit 7A
Structure
Interactors	20 interactors: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	Protein Binding
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation
Pathways	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
GWAS	Hip circumference adjusted for BMI ( 34021172 ) Red blood cell count ( 32888494 )
Entrez ID	50813
HPRD ID	16736
Ensembl ID	ENSG00000111652
Uniprot IDs	Q9UBW8
PDB IDs	4D10 4D18 4WSN
GO Terms Enriched among Interactors ?	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process PML Body Regulation Of Blood Vessel Endothelial Cell Migration Nucleus Cellular Response To Hypoxia DeNEDDylase Activity Cellular Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Protein Phosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Phosphorylation Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration GTPase Inhibitor Activity Eukaryotic Translation Initiation Factor 3 Complex Type II Interferon-mediated Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Cellular Response To Angiotensin Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Response To Hypoxia Positive Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction By P53 Class Mediator Response To Angiotensin Nucleoplasm Negative Regulation Of Programmed Cell Death Cytoplasm Response To Decreased Oxygen Levels