COPS7A and PMF1

Number of citations: 23 (PubMedID 12020345)
Data Source: HPRD (two hybrid)

		COPS7A	PMF1
Name		COP9 signalosome subunit 7A	polyamine modulated factor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Golgi Apparatus Cytosol
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Transcription By RNA Polymerase II Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription Cell Division
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Red blood cell count ( 32888494 )	Estimated glomerular filtration rate ( 30604766 ) Intracerebral hemorrhage ( 24656865 ) Longevity (age >99th survival percentile) ( 31413261 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) White matter hyperintensity burden ( 25663218 )
Interacting Genes		20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	23 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L USHBP1
Entrez ID		50813	11243
HPRD ID		16736	11441
Ensembl ID		ENSG00000111652	ENSG00000160783
Uniprot IDs		Q9UBW8	Q6P1K2
PDB IDs		4D10 4D18 4WSN	5LSJ 5LSK 8PPR 8Q5H
GO Terms Enriched among Interactors		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process PML Body Regulation Of Blood Vessel Endothelial Cell Migration Nucleus Cellular Response To Hypoxia DeNEDDylase Activity Cellular Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Protein Phosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Phosphorylation Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration GTPase Inhibitor Activity Eukaryotic Translation Initiation Factor 3 Complex Type II Interferon-mediated Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Cellular Response To Angiotensin Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Response To Hypoxia Positive Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction By P53 Class Mediator Response To Angiotensin Nucleoplasm Negative Regulation Of Programmed Cell Death Cytoplasm Response To Decreased Oxygen Levels	Protein Deneddylation Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification Skeletal Muscle Satellite Cell Proliferation COP9 Signalosome COP9 Signalosome Assembly MIS12/MIND Type Complex Spindle Pole Kinetochore Skeletal Muscle Cell Proliferation Positive Regulation Of Cell Size Kinetochore Assembly Centrosome Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Kinetochore Organization Microtubule Cytoskeleton Organization Outer Kinetochore Protein Neddylation Protein-containing Complex Protein Modification By Small Protein Removal Post-translational Protein Modification Ossification CTP Binding DATP Binding Regulation Of Protein Modification Process Response To Antibiotic Protein Tyrosine Kinase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Glutathione Biosynthetic Process Mediator Complex Spindle Organization Chromosome, Centromeric Region Negative Regulation Of ARF Protein Signal Transduction Attachment Of Spindle Microtubules To Kinetochore Cell Redox Homeostasis Regulation Of Response To Wounding Regulation Of Neuroblast Proliferation Regulation Of Cell Division Muscle Cell Proliferation Protein Modification By Small Protein Conjugation