SRSF1 and HNRNPA0

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		SRSF1	HNRNPA0
Gene Name		serine/arginine-rich splicing factor 1	heterogeneous nuclear ribonucleoprotein A0
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Nucleotide Binding RNA Binding AU-rich Element Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Gene Expression MRNA 3'-end Processing Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Cardiac Muscle Contraction	MRNA Splicing, Via Spliceosome MRNA Processing Inflammatory Response RNA Splicing Gene Expression Response To Lipopolysaccharide 3'-UTR-mediated MRNA Stabilization
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF2 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	15 interactors: CCT3 CIRBP DDX5 HNRNPF HNRNPH2 HNRNPH3 HNRNPK IL7R MAPK6 MAPKAPK2 MTNR1A MTNR1B NKX3-1 SRSF1 U2AF2
Entrez ID		6426	10949
HPRD ID		02887	17112
Ensembl ID			ENSG00000177733
Uniprot IDs		Q07955 Q59FA2	Q13151
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Ribonucleoprotein Complex Assembly MRNA Transport Nuclear Export Termination Of RNA Polymerase II Transcription Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing RNA Transport RNA Localization RNA 3'-end Processing DNA-templated Transcription, Termination Negative Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Negative Regulation Of RNA Splicing Cellular Metabolic Process MRNA Splice Site Selection Transcription From RNA Polymerase II Promoter Cytoplasmic Transport Cellular Macromolecular Complex Assembly Metabolic Process Cellular Component Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Establishment Of Localization In Cell RNA Biosynthetic Process Intracellular Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Localization Positive Regulation Of Gene Expression Peptidyl-threonine Phosphorylation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of RNA Splicing Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Gene Expression MRNA Stabilization Positive Regulation Of Gene Expression RNA Metabolic Process Termination Of RNA Polymerase II Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus MRNA Export From Nucleus Regulation Of Gene Expression DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Interleukin-7-mediated Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Androgen Secretion Regulation Of Lipid Transport Transcription From RNA Polymerase II Promoter Negative Regulation Of Estrogen Receptor Binding RNA 3'-end Processing Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus MRNA 5'-splice Site Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Nucleobase-containing Compound Metabolic Process RNA Transport Cell Growth G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macropinocytosis Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Binding
Tagcloud ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized	atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates posttranscriptional releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired
Tagcloud (Difference) ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized	atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired
Tagcloud (Intersection) ?		posttranscriptional