SRSF1 and PRPF4

Number of citations of the paper that reports this interaction (PMID 11418604)
16

Data Source:
HPRD (in vitro)

		SRSF1	PRPF4
Gene Name		serine/arginine-rich splicing factor 1	pre-mRNA processing factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Protein Binding U6 SnRNA Binding U4 SnRNA Binding
	Biological Process	MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Gene Expression MRNA 3'-end Processing Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Cardiac Muscle Contraction	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF2 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	12 interactors: APP ATP5J2 CLK1 GPKOW NHP2L1 PPIH PRPF3 PRPF31 SRSF1 TGFBR1 U2AF1 WBP4
Entrez ID		6426	9128
HPRD ID		02887	08479
Ensembl ID			ENSG00000136875
Uniprot IDs		Q07955 Q59FA2	O43172 Q5T1M7
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG	1MZW
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Ribonucleoprotein Complex Assembly MRNA Transport Nuclear Export Termination Of RNA Polymerase II Transcription Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing RNA Transport RNA Localization RNA 3'-end Processing DNA-templated Transcription, Termination Negative Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Negative Regulation Of RNA Splicing Cellular Metabolic Process MRNA Splice Site Selection Transcription From RNA Polymerase II Promoter Cytoplasmic Transport Cellular Macromolecular Complex Assembly Metabolic Process Cellular Component Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Establishment Of Localization In Cell RNA Biosynthetic Process Intracellular Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Localization Positive Regulation Of Gene Expression Peptidyl-threonine Phosphorylation	MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Splicing MRNA 3'-end Processing Spliceosomal Tri-snRNP Complex Assembly Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Assembly Cellular Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Peptidyl-threonine Phosphorylation MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of RNA Splicing Collateral Sprouting In Absence Of Injury Cellular Component Assembly Peptidyl-serine Phosphorylation Nuclear Export MRNA Transport RNA Transport Regulation Of Protein Binding Collateral Sprouting Axon Midline Choice Point Recognition MRNA 5'-splice Site Recognition RNA Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Macromolecular Complex Assembly Parathyroid Gland Development Neuron Remodeling Intracellular Transport Endothelial Cell Activation
Tagcloud ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized
Tagcloud (Difference) ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized
Tagcloud (Intersection) ?