SRSF1 and NFYA

Number of citations of the paper that reports this interaction (PMID 15243141)
10

Data Source:
HPRD (in vitro, in vivo)

		SRSF1	NFYA
Gene Name		serine/arginine-rich splicing factor 1	nuclear transcription factor Y, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Core Promoter Sequence-specific DNA Binding Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Gene Expression MRNA 3'-end Processing Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Cardiac Muscle Contraction	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF2 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	37 interactors: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CEBPA CSNK2A1 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TP53 USF1 USF2 ZHX1 ZHX2 ZHX3
Entrez ID		6426	4800
HPRD ID		02887	01793
Ensembl ID
Uniprot IDs		Q07955 Q59FA2	P23511
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG	4AWL
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Ribonucleoprotein Complex Assembly MRNA Transport Nuclear Export Termination Of RNA Polymerase II Transcription Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing RNA Transport RNA Localization RNA 3'-end Processing DNA-templated Transcription, Termination Negative Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Negative Regulation Of RNA Splicing Cellular Metabolic Process MRNA Splice Site Selection Transcription From RNA Polymerase II Promoter Cytoplasmic Transport Cellular Macromolecular Complex Assembly Metabolic Process Cellular Component Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Establishment Of Localization In Cell RNA Biosynthetic Process Intracellular Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Localization Positive Regulation Of Gene Expression Peptidyl-threonine Phosphorylation	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Viral Process Cellular Metabolic Process Positive Regulation Of Transcription By Glucose Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Negative Regulation Of Nucleic Acid-templated Transcription Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Late Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cellular Response To Nutrient Levels Regulation Of Cell Cycle
Tagcloud ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Difference) ?		altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Intersection) ?