SRSF1 and U2AF2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		SRSF1	U2AF2
Description		serine and arginine rich splicing factor 1	U2 small nuclear RNA auxiliary factor 2
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding RS Domain Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding Molecular Function Inhibitor Activity
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of RNA Splicing Protein Localization To Nucleus Regulation Of RNA Splicing MRNA Stabilization Oligodendrocyte Differentiation MRNA Transport Cardiac Muscle Contraction Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Liver Regeneration Protein Localization To P-body	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation
Drugs		Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		53 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK13 CDK6 CDR1 CLK1 CLK2 CLK3 CLK4 CPSF7 DANCR DIDO1 DYRK1A FOXP1 GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L LUC7L3 NFYA NXF1 PPARG PRKN PRMT1 PRP4K PRPF4 PSIP1 RNF10 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	71 interacting genes: - APBB1 ATXN1 BEND7 CCAR1 CDC42 CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OGT OTUB2 PHF5A PIN1 POLR2A PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B3 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 USP7 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		6426	11338
HPRD ID		02887	01872
Ensembl ID		ENSG00000136450	ENSG00000063244
Uniprot IDs		Q07955 Q59FA2	P26368
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG 8QO9	1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX 7S3A 7S3B 7S3C 7SN6 8P25 9C7A 9C7B 9DWU
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Speck RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleus Protein-RNA Complex Assembly RNA Binding RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Protein Serine/threonine Kinase Activity MRNA Splicing, Via Spliceosome Protein Serine Kinase Activity MRNA Splice Site Recognition Nucleic Acid Binding Protein-containing Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-containing Complex Organization Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Gene Expression U2-type Prespliceosome Regulation Of Macromolecule Biosynthetic Process Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Protein Tyrosine Kinase Activity Identical Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Metabolic Process Nucleic Acid Binding Nucleoplasm Regulation Of RNA Splicing Nucleic Acid Metabolic Process Nucleus Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process U2AF Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Positive Regulation Of Biosynthetic Process RS Domain Binding Pre-mRNA 3'-splice Site Binding Protein-containing Complex Assembly U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex MRNA Splice Site Recognition Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Splicing
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