SRSF1 and LUC7L

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF1	LUC7L
Description		serine and arginine rich splicing factor 1	LUC7 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	U1 SnRNP U2-type Prespliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding RS Domain Binding	MRNA Binding Protein Binding Identical Protein Binding RS Domain Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of RNA Splicing Protein Localization To Nucleus Regulation Of RNA Splicing MRNA Stabilization Oligodendrocyte Differentiation MRNA Transport Cardiac Muscle Contraction Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Liver Regeneration Protein Localization To P-body	MRNA Splice Site Recognition Negative Regulation Of Striated Muscle Tissue Development
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs		Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Heel bone mineral density ( 30598549) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 28453575 27863252 20139978 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		53 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK13 CDK6 CDR1 CLK1 CLK2 CLK3 CLK4 CPSF7 DANCR DIDO1 DYRK1A FOXP1 GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L LUC7L3 NFYA NXF1 PPARG PRKN PRMT1 PRP4K PRPF4 PSIP1 RNF10 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	20 interacting genes: ANTKMT APPL1 CALM1 CHERP CLK2 CTNNBL1 DPYSL2 EIF4ENIF1 FBXO25 GADD45G PRDX1 PRMT5 SRPK2 SRRM4 SRSF1 SRSF6 SRSF7 SRSF8 TCERG1 TSC1
Entrez ID		6426	55692
HPRD ID		02887	08476
Ensembl ID		ENSG00000136450	ENSG00000007392
Uniprot IDs		Q07955 Q59FA2	A8MYV2 Q1W6G4 Q9NQ29
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG 8QO9
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Speck RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleus Protein-RNA Complex Assembly RNA Binding RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Protein Serine/threonine Kinase Activity MRNA Splicing, Via Spliceosome Protein Serine Kinase Activity MRNA Splice Site Recognition Nucleic Acid Binding Protein-containing Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-containing Complex Organization Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Gene Expression U2-type Prespliceosome Regulation Of Macromolecule Biosynthetic Process Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Protein Tyrosine Kinase Activity Identical Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Splicing Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Binding RNA Binding Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Nucleus Protein-RNA Complex Assembly Protein Kinase B Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Liver Regeneration Macromolecule Metabolic Process MRNA Splice Site Recognition Protein Methylation Regulation Of Cell Cycle Positive Regulation Of RNA Splicing Protein Localization To Nucleus Memory T Cell Differentiation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Animal Organ Regeneration Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization To P-body Peptidyl-arginine N-methylation Positive Regulation Of Macropinocytosis Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Stabilization Identical Protein Binding
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