DEF6 and PLSCR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DEF6	PLSCR1
Description		DEF6 guanine nucleotide exchange factor	phospholipid scramblase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Hydrolase Activity SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport To The Plasma Membrane	Phosphatidylserine Biosynthetic Process Lipid Transport Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469 33493351) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	132 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MDK MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PPDPF PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG THBS1 TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764
Entrez ID		50619	5359
HPRD ID		10869	08855
Ensembl ID		ENSG00000023892	ENSG00000188313
Uniprot IDs		Q9H4E7	C9J7K9 O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Cytosol Positive Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Beta Selection Small GTPase-mediated Signal Transduction Focal Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Activation Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Leukocyte Proliferation Regulation Of Neuron Differentiation Positive Regulation Of Leukocyte Chemotaxis Supramolecular Fiber Organization Positive Regulation Of Cell Adhesion Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Regulation Of Leukocyte Migration Postsynapse Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Membrane Invagination Cytoplasm Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of T Cell Activation Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation CD4 Receptor Binding Regulation Of Cell Shape Regulation Of Granulocyte Chemotaxis Regulation Of Postsynapse Organization Positive Regulation Of Chemotaxis Thioesterase Binding Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Protein Kinase Binding Leukocyte Aggregation Regulation Of Substrate Adhesion-dependent Cell Spreading	Enzyme Binding Ephrin Receptor Binding Protein Binding Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Keratin Filament Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Intermediate Filament Response To Growth Factor Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Helper T Cell Diapedesis Shc-EGFR Complex Positive Regulation Of Cell-substrate Adhesion Regulation Of Superoxide Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Response To Lipid Hair Cycle Apoptotic Process Regulation Of Focal Adhesion Assembly Regulation Of MAPK Cascade Cerebellar Neuron Development Regulation Of Apoptotic Process Protein Tyrosine Kinase Activator Activity Cellular Response To Lipid Morphogenesis Of A Branching Structure ERBB Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Cell-substrate Junction Organization Gland Development Regulation Of RNA Biosynthetic Process Programmed Cell Death Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding System Development Regulation Of Cell Population Proliferation Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Regulation Of Cell-matrix Adhesion Positive Regulation Of Superoxide Anion Generation Central Nervous System Neuron Development
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