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DEF6 and RAC2
Number of citations of the paper that reports this interaction (PubMedID
15023524
)
0
Data Source:
HPRD
(in vitro)
DEF6
RAC2
Description
DEF6 guanine nucleotide exchange factor
Rac family small GTPase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Filopodium
Cell Projection
Perinuclear Region Of Cytoplasm
Nuclear Envelope
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Membrane
Lamellipodium
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Cell Projection
NADPH Oxidase Complex
Extracellular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Nucleotide Binding
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
Protein Kinase Regulator Activity
Protein Kinase Binding
Biological Process
Regulation Of Small GTPase Mediated Signal Transduction
Vesicle-mediated Transport To The Plasma Membrane
Chemotaxis
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Hydrogen Peroxide Metabolic Process
Positive Regulation Of Lamellipodium Assembly
Regulation Of Cell-substrate Adhesion
Cell Projection Assembly
Actin Cytoskeleton Organization
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of T Cell Proliferation
Superoxide Anion Generation
Erythrocyte Enucleation
Regulation Of Mast Cell Degranulation
Bone Resorption
Respiratory Burst
Regulation Of Respiratory Burst
Regulation Of Mast Cell Chemotaxis
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Lymphocyte Aggregation
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Neutrophil Migration
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
RHOA GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
GPVI-mediated activation cascade
ROS and RNS production in phagocytes
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
PCP/CE pathway
RHO GTPases Activate NADPH Oxidases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RAC2 GTPase cycle
Drugs
Dextromethorphan
Diseases
Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS
Alanine aminotransferase levels (
33547301
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Height (
18391951
33713608
)
Hip circumference adjusted for BMI (
34021172
)
Lymphocyte count (
32888494
)
Neutrophil count (
32888494
)
Systemic lupus erythematosus (
28714469
33493351
)
Waist circumference adjusted for body mass index (
34021172
)
White blood cell count (
32888494
)
Celiac disease (
31591516
)
Graves' disease (
23612905
)
Longevity (
20834067
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Response to methotrexate in juvenile idiopathic arthritis (
24709693
)
Type 1 diabetes (
25751624
)
Interacting Genes
32 interacting genes:
APP
ARHGAP22
BEGAIN
CCDC88B
CDC42
CDC42EP1
EIF4ENIF1
GOLGA6A
GOLGA6L9
HOMEZ
INCA1
INTS2
KIAA1328
KRT31
L3MBTL3
LCK
PBXIP1
PLSCR1
PSMA1
PTK2
RAC1
RAC2
RAPGEF4
RASAL3
REL
RHOA
SAP18
SLU7
TCF4
TEPSIN
ZAP70
ZNF688
21 interacting genes:
ACTB
ADAM22
AFG3L2
AGAP2
ARFIP2
ARHGDIA
ARHGDIB
CDC42
CHGB
CUL1
DEF6
DOCK2
GDI1
HDAC7
ICMT
NCF2
NOS2
NOXA1
RTKN
SMAD1
SMAD4
Entrez ID
50619
5880
HPRD ID
10869
03628
Ensembl ID
ENSG00000023892
ENSG00000128340
Uniprot IDs
Q9H4E7
P15153
V9H0H7
PDB IDs
1DS6
2W2T
2W2V
2W2X
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Immune System Process
Cytosol
Positive Regulation Of Leukocyte Migration
Regulation Of Cell Adhesion
Beta Selection
Small GTPase-mediated Signal Transduction
Focal Adhesion
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cell Activation
Intracellular Signaling Cassette
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Leukocyte Proliferation
Regulation Of Neuron Differentiation
Positive Regulation Of Leukocyte Chemotaxis
Supramolecular Fiber Organization
Positive Regulation Of Cell Adhesion
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Lamellipodium Organization
Erythrocyte Enucleation
Lymphocyte Aggregation
Regulation Of Cell-substrate Adhesion
Regulation Of Lamellipodium Assembly
Regulation Of Leukocyte Migration
Postsynapse
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Cell Activation
Regulation Of T Cell Activation
Regulation Of Immune System Process
Membrane Invagination
Cytoplasm
Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of T Cell Activation
Non-canonical Wnt Signaling Pathway
Regulation Of Lamellipodium Organization
Peptidyl-tyrosine Phosphorylation
CD4 Receptor Binding
Regulation Of Cell Shape
Regulation Of Granulocyte Chemotaxis
Regulation Of Postsynapse Organization
Positive Regulation Of Chemotaxis
Thioesterase Binding
Regulation Of Leukocyte Proliferation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Protein Kinase Binding
Leukocyte Aggregation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Intracellular Signaling Cassette
Small GTPase-mediated Signal Transduction
Small GTPase Binding
Cardiac Conduction System Development
Actin Cytoskeleton Organization
Cytosol
Rho GDP-dissociation Inhibitor Activity
Intracellular Signal Transduction
Actin Filament-based Process
GTPase Activator Activity
Superoxide Metabolic Process
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Superoxide-generating NADPH Oxidase Activator Activity
Cardiac Muscle Tissue Development
Rho Protein Signal Transduction
I-SMAD Binding
NADPH Oxidase Complex
Protein Kinase Binding
Cytoplasm
Reactive Oxygen Species Metabolic Process
GTP-dependent Protein Binding
Superoxide Anion Generation
SMAD Protein Signal Transduction
Negative Regulation Of Protein Catabolic Process
Cortical Cytoskeleton
Regulation Of Small GTPase Mediated Signal Transduction
Striated Muscle Tissue Development
Positive Regulation Of Norepinephrine Uptake
Cellular Response To Cytochalasin B
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
GTP Binding
Muscle Tissue Development
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Female Gonad Morphogenesis
S-adenosylmethioninamine Metabolic Process
Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity
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Tagcloud (Difference)
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Tagcloud (Intersection)
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