PLSCR1 and EFEMP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PLSCR1	EFEMP2
Gene Name		phospholipid scramblase 1	EGF containing fibulin-like extracellular matrix protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding	Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Signal Transduction Blood Coagulation Extracellular Matrix Organization
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764	50 interactors: APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		5359	30008
HPRD ID		08855	05221
Ensembl ID		ENSG00000188313	ENSG00000172638
Uniprot IDs		B4DTE8 O15162	O95967 Q9H3D5
PDB IDs		1Y2A	2KL7
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Response To Salt Stress Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process System Development Developmental Process Phospholipid Scrambling Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Heart Contraction Neuron Death Pons Development Anatomical Structure Development Central Nervous System Development Positive Regulation Of Gene Expression Blood Vessel Development Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?