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PLSCR1 and OGDH
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
HPRD
(two hybrid)
PLSCR1
OGDH
Description
phospholipid scramblase 1
oxoglutarate dehydrogenase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Mitochondrion
Mitochondrial Matrix
Mitochondrial Membrane
Oxoglutarate Dehydrogenase Complex
Molecular Function
Magnesium Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Virus Receptor Activity
DNA Binding
Nuclease Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Hydrolase Activity
SH3 Domain Binding
Phospholipid Scramblase Activity
Enzyme Binding
Lead Ion Binding
CD4 Receptor Binding
Mercury Ion Binding
Oxoglutarate Dehydrogenase (succinyl-transferring) Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors
Thiamine Pyrophosphate Binding
Heat Shock Protein Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Biological Process
Phosphatidylserine Biosynthetic Process
Lipid Transport
Apoptotic Process
Acute-phase Response
Response To Lead Ion
Positive Regulation Of Gene Expression
Plasma Membrane Phospholipid Scrambling
Platelet Activation
Regulation Of Mast Cell Activation
Response To Interferon-beta
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Symbiont Entry Into Host Cell
Negative Regulation Of Phagocytosis
Defense Response To Virus
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Chromosome Separation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Generation Of Precursor Metabolites And Energy
Glycolytic Process
Tricarboxylic Acid Cycle
2-oxoglutarate Metabolic Process
Succinyl-CoA Metabolic Process
NAD+ Metabolic Process
Cerebellar Cortex Development
Striatum Development
Hippocampus Development
Thalamus Development
Pyramidal Neuron Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Olfactory Bulb Mitral Cell Layer Development
Pathways
Glycine degradation
Mitochondrial protein degradation
OGDH complex synthesizes succinyl-CoA from 2-OG
Drugs
NADH
Valproic acid
Xanthinol
Diseases
Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS
Gut microbiota (beta diversity) (
27723756
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Low density lipoprotein cholesterol levels (
32154731
)
Lung cancer in never smokers (
28604730
)
Systolic blood pressure change trajectory (
27980656
)
Interacting Genes
132 interacting genes:
ABL1
ADAMTSL4
ADCY7
ANXA11
APP
ARNT2
ATG12
ATN1
BACE1
BCL6B
C10orf62
CATSPER1
CCDC33
CCER1
CDC42EP1
CHRD
CNTFR
CPSF6
CRK
CRKL
CRY1
CTBP1-DT
CTSZ
DAZAP2
DDIAS
DEF6
DEPP1
DHRS1
DLK2
DMRT3
DOCK2
DTX2
EFEMP2
EGFR
ENKD1
EP300
ESR2
EWSR1
EXD3
FAM107A
FBLN1
FBXL18
FRAT1
FRS3
GDPD5
GLRX3
GNAI2
GPRIN2
HEY2
HOXA1
HOXA9
HOXB6
HRG
ILF3
INTS11
IP6K2
IQCN
KIF1A
KRTAP10-11
KRTAP10-3
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP9-2
LASP1
LCE2D
LCE3C
LCE4A
LGALS9C
LINC00663
LINC01547
LONRF1
MAPK6
MDK
MED15
MGAT5B
MVP
NECAP2
NEU4
NOC4L
NPDC1
NR0B2
NTN4
OGDH
P2RY6
PCED1A
PGLS
PHLDA1
PITX1
PKD2
PLSCR3
PLSCR4
PML
PPDPF
PRKCD
PRR13
RAMAC
RASD1
RBL1
RERE
RGS3
RXRB
SCNM1
SF1
SHC1
SLC25A6
SLC35A2
SLPI
SMARCC1
SMCP
SPATA8
SPG7
SPRY2
SRC
STK16
TFG
THBS1
TRAF4
TRIM42
VASP
VPS37C
VSIR
YIPF3
ZBTB16
ZNF417
ZNF581
ZNF587
ZNF638
ZNF688
ZNF764
6 interacting genes:
ANXA2
DLD
DLST
HSD17B10
PLSCR1
USP7
Entrez ID
5359
4967
HPRD ID
08855
08938
Ensembl ID
ENSG00000188313
ENSG00000105953
Uniprot IDs
C9J7K9
O15162
A0A140VJQ5
B4DH65
B4E3E9
E9PCR7
E9PDF2
Q02218
PDB IDs
1Y2A
3ERY
7WGR
8I0K
Enriched GO Terms of Interacting Partners
?
Enzyme Binding
Ephrin Receptor Binding
Protein Binding
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell-substrate Adhesion
Cellular Response To Transforming Growth Factor Beta Stimulus
Keratin Filament
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Intermediate Filament
Response To Growth Factor
Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Helper T Cell Diapedesis
Shc-EGFR Complex
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Superoxide Metabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Response To Lipid
Hair Cycle
Apoptotic Process
Regulation Of Focal Adhesion Assembly
Regulation Of MAPK Cascade
Cerebellar Neuron Development
Regulation Of Apoptotic Process
Protein Tyrosine Kinase Activator Activity
Cellular Response To Lipid
Morphogenesis Of A Branching Structure
ERBB Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of Cell-substrate Junction Organization
Gland Development
Regulation Of RNA Biosynthetic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Non-membrane Spanning Protein Tyrosine Kinase Activity
Epidermal Growth Factor Binding
System Development
Regulation Of Cell Population Proliferation
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Cell Migration
Regulation Of Programmed Cell Death
Regulation Of Cell-matrix Adhesion
Positive Regulation Of Superoxide Anion Generation
Central Nervous System Neuron Development
Oxoadipate Dehydrogenase Complex
Oxoglutarate Dehydrogenase Complex
Succinyl-CoA Metabolic Process
Amino Acid Catabolic Process
2-oxoglutarate Metabolic Process
Branched-chain Amino Acid Catabolic Process
Branched-chain Amino Acid Metabolic Process
Acetyl-CoA Metabolic Process
Carboxylic Acid Catabolic Process
Amino Acid Metabolic Process
Aspartate Family Amino Acid Metabolic Process
Negative Regulation Of Endocytosis
Dihydrolipoyl Dehydrogenase (NADH) Activity
2-oxoglutarate Decarboxylation To Succinyl-CoA
Acetyltransferase Complex
Dihydrolipoyllysine-residue Succinyltransferase Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Cholate 7-alpha-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Mitochondrial Matrix
Proteinogenic Amino Acid Catabolic Process
L-amino Acid Catabolic Process
Serine-type Endopeptidase Inhibitor Activity
Acyl-CoA Metabolic Process
Dicarboxylic Acid Metabolic Process
Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
AnxA2-p11 Complex
PCSK9-AnxA2 Complex
Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Succinyl-CoA Biosynthetic Process
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
Brexanolone Metabolic Process
Lead Ion Binding
Positive Regulation Of Platelet-derived Growth Factor Production
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Receptor Catabolic Process
Positive Regulation Of Intracellular Cholesterol Transport
Regulation Of Vesicle-mediated Transport
Acrosomal Matrix
L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
Mitochondrial Ribonuclease P Complex
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Mitochondrial TRNA Methylation
Phosphatidylserine Biosynthetic Process
Mercury Ion Binding
Phosphatidylserine Exposure On Apoptotic Cell Surface
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Tagcloud (Intersection)
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