PLSCR1 and OGDH

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PLSCR1	OGDH
Gene Name		phospholipid scramblase 1	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Thiamine Pyrophosphate Binding Heat Shock Protein Binding Oxoglutarate Dehydrogenase (NAD+) Activity Metal Ion Binding Chaperone Binding
	Biological Process	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process NADH Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Olfactory Bulb Mitral Cell Layer Development
Pathways			Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs			NADH Valproic Acid
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764	3 interactors: DLD DLST PLSCR1
Entrez ID		5359	4967
HPRD ID		08855	08938
Ensembl ID		ENSG00000188313	ENSG00000105953
Uniprot IDs		B4DTE8 O15162	B4E3E9 E9PCR7 E9PDF2 E9PFG7 Q02218
PDB IDs		1Y2A	3ERY
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation	Lysine Catabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Cellular Amino Acid Catabolic Process Cellular Respiration Carboxylic Acid Catabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Alpha-amino Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Phosphatidylserine Biosynthetic Process Generation Of Precursor Metabolites And Energy Cellular Amino Acid Metabolic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Detoxification Of Mercury Ion Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Sperm Capacitation Branched-chain Amino Acid Catabolic Process Response To Interferon-beta Acetyl-CoA Metabolic Process Response To Mercury Ion Phosphatidylserine Metabolic Process Positive Regulation Of ATPase Activity Regulation Of Mast Cell Activation Acute-phase Response Regulation Of ATPase Activity Mitochondrial Electron Transport, NADH To Ubiquinone Organophosphate Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Viral Genome Replication Organic Acid Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Acyl-CoA Metabolic Process Regulation Of Membrane Lipid Distribution Regulation Of Viral Genome Replication Oxidative Phosphorylation Negative Regulation Of Viral Process Acute Inflammatory Response Cellular Nitrogen Compound Metabolic Process Regulation Of Fatty Acid Metabolic Process Phospholipid Transport Oxidation-reduction Process Nitrogen Compound Metabolic Process Respiratory Electron Transport Chain Cell Redox Homeostasis Electron Transport Chain
Tagcloud ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers
Tagcloud (Difference) ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers
Tagcloud (Intersection) ?