PLSCR1 and NECAP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PLSCR1	NECAP2
Gene Name		phospholipid scramblase 1	NECAP endocytosis associated 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome	Intracellular Plasma Membrane Coated Pit Clathrin Vesicle Coat
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Endocytosis Protein Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764	5 interactors: AP2B1 APP NMI PLSCR1 TRAF2
Entrez ID		5359	55707
HPRD ID		08855	07674
Ensembl ID		ENSG00000188313	ENSG00000157191
Uniprot IDs		B4DTE8 O15162	Q9NVZ3
PDB IDs		1Y2A
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation	Defense Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Immune System Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Positive Regulation Of Innate Immune Response Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Apoptotic Process Platelet Activation Programmed Cell Death Positive Regulation Of Hydrolase Activity Cell Death Death Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Innate Immune Response Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Phosphatidylserine Biosynthetic Process Regulation Of Signaling Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Immune System Process Positive Regulation Of Proteolysis Neuron Remodeling Response To Stress Positive Regulation Of Protein Homodimerization Activity Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Cellular Response To Nitric Oxide Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Axon Guidance Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Regulation Of Peptidase Activity Response To Oxidative Stress Blood Coagulation Inflammatory Response Hemostasis Regulation Of Cell Activation Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Cellular Copper Ion Homeostasis Response To External Stimulus Regulation Of Protein Homodimerization Activity
Tagcloud ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	actin anxa2 automated beyond cofilin coincided dephosphorylation depletion dnajc6 egfr endocytosis endosomes fgd6 gdi2 hax1 hbl100 inactive knockdown mb mda mediator mediators re rnas s3a s3e semi severing tnbc
Tagcloud (Difference) ?		actions adaptor adding anchorage attenuation blocking colorectal crc crcs effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic	actin anxa2 automated beyond cofilin coincided depletion dnajc6 egfr endocytosis endosomes fgd6 gdi2 hax1 hbl100 inactive knockdown mb mda mediator mediators re rnas s3a s3e semi severing tnbc
Tagcloud (Intersection) ?		dephosphorylation