DEF6 and KIAA1328

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEF6	KIAA1328
Description		DEF6 guanine nucleotide exchange factor	KIAA1328
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport To The Plasma Membrane
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469 33493351) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Body mass index ( 28552196) Ferritin levels ( 33491795) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Periodontal disease-related phenotype (Socransky) ( 24347629) Reaction time ( 29844566) Simvastatin-induced myopathy ( 31220337) Weight ( 28552196)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	29 interacting genes: AMOT ANKS1A ATG5 CARD9 CCDC13 CENPP CEP290 CFAP206 COPB1 DEF6 EAF1 EEF2KMT FAM161A FAM161B GOLGA1 LMO1 LNX1 MTMR9 NEK6 PICK1 PKN1 PRKAA2 SYCE1L TSG101 TSGA10 TTC23 TXLNA TXLNB ZGPAT
Entrez ID		50619	57536
HPRD ID		10869	17211
Ensembl ID		ENSG00000023892	ENSG00000150477
Uniprot IDs		Q9H4E7	Q86T90
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Cytosol Positive Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Beta Selection Small GTPase-mediated Signal Transduction Focal Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Activation Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Leukocyte Proliferation Regulation Of Neuron Differentiation Positive Regulation Of Leukocyte Chemotaxis Supramolecular Fiber Organization Positive Regulation Of Cell Adhesion Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Regulation Of Leukocyte Migration Postsynapse Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Membrane Invagination Cytoplasm Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of T Cell Activation Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation CD4 Receptor Binding Regulation Of Cell Shape Regulation Of Granulocyte Chemotaxis Regulation Of Postsynapse Organization Positive Regulation Of Chemotaxis Thioesterase Binding Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Protein Kinase Binding Leukocyte Aggregation Regulation Of Substrate Adhesion-dependent Cell Spreading	Regulation Of Stress Granule Assembly Protein-containing Complex Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Cytoskeleton
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