DEF6 and ARHGAP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEF6	ARHGAP22
Description		DEF6 guanine nucleotide exchange factor	Rho GTPase activating protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport To The Plasma Membrane	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469 33493351) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Femur bone mineral density x serum urate levels interaction ( 34046847) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	8 interacting genes: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA
Entrez ID		50619	58504
HPRD ID		10869	12476
Ensembl ID		ENSG00000023892	ENSG00000128805
Uniprot IDs		Q9H4E7	A0A2X0SFC0 Q7Z5H3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Cytosol Positive Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Beta Selection Small GTPase-mediated Signal Transduction Focal Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Activation Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Leukocyte Proliferation Regulation Of Neuron Differentiation Positive Regulation Of Leukocyte Chemotaxis Supramolecular Fiber Organization Positive Regulation Of Cell Adhesion Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Regulation Of Leukocyte Migration Postsynapse Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Membrane Invagination Cytoplasm Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of T Cell Activation Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation CD4 Receptor Binding Regulation Of Cell Shape Regulation Of Granulocyte Chemotaxis Regulation Of Postsynapse Organization Positive Regulation Of Chemotaxis Thioesterase Binding Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Protein Kinase Binding Leukocyte Aggregation Regulation Of Substrate Adhesion-dependent Cell Spreading	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity
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