DEF6 and CDC42EP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DEF6	CDC42EP1
Description		DEF6 guanine nucleotide exchange factor	CDC42 effector protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Cell Projection Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Endomembrane System Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Small GTPase Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport To The Plasma Membrane	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Cell-cell Adhesion
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469 33493351) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	13 interacting genes: ARMC7 CDC42 DEF6 FHL3 KRTAP4-12 MAPKAP1 MDFI OGT PLSCR1 PRKAA2 RBPMS RHOQ SAT1
Entrez ID		50619	11135
HPRD ID		10869	07303
Ensembl ID		ENSG00000023892	ENSG00000128283
Uniprot IDs		Q9H4E7	Q00587
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Cytosol Positive Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Beta Selection Small GTPase-mediated Signal Transduction Focal Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Activation Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Leukocyte Proliferation Regulation Of Neuron Differentiation Positive Regulation Of Leukocyte Chemotaxis Supramolecular Fiber Organization Positive Regulation Of Cell Adhesion Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Regulation Of Leukocyte Migration Postsynapse Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Membrane Invagination Cytoplasm Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of T Cell Activation Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation CD4 Receptor Binding Regulation Of Cell Shape Regulation Of Granulocyte Chemotaxis Regulation Of Postsynapse Organization Positive Regulation Of Chemotaxis Thioesterase Binding Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Protein Kinase Binding Leukocyte Aggregation Regulation Of Substrate Adhesion-dependent Cell Spreading	GBD Domain Binding TOR Signaling Organelle Organization Protein Kinase Binding Cytosol Filopodium Endothelin Receptor Signaling Pathway Involved In Heart Process Substantia Nigra Development Regulation Of Filopodium Assembly Neural Nucleus Development Positive Regulation Of Filopodium Assembly Intracellular Signal Transduction Storage Vacuole Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Protein Localization To Lysosome Cellular Response To Glucose Stimulus Positive Regulation Of TOR Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Negative Regulation Of Translational Initiation [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Intracellular Glucose Homeostasis Positive Regulation Of Translational Initiation Regulation Of Purine Nucleotide Metabolic Process Cellular Response To Nutrient Levels TORC1 Signaling Response To Hormone Cellular Response To Hormone Stimulus Diamine N-acetyltransferase Activity Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Small GTPase Mediated Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Peptide Hormone Response To Insulin Regulation Of Insulin Receptor Signaling Pathway Protein O-acetylglucosaminyltransferase Activity Insulin Receptor Signaling Pathway Establishment Of Cell Polarity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?