DEF6 and CDC42EP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DEF6	CDC42EP1
Gene Name		differentially expressed in FDCP 6 homolog (mouse)	CDC42 effector protein (Rho GTPase binding) 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Focal Adhesion Actin Cytoskeleton
	Molecular Function		Rho GTPase Activator Activity Protein Binding GTP-Rho Binding
	Biological Process		Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity
Pathways
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		15 interactors: APP BEGAIN CDC42 CDC42EP1 EIF4ENIF1 HOMEZ LCK PBXIP1 PLSCR1 PTK2 RAC1 RAC2 RHOA TCF4 ZAP70	10 interactors: CDC42 DEF6 FHL3 KRTAP4-12 MAPKAP1 MDFI PLSCR1 RBPMS RHOJ RHOQ
Entrez ID		50619	11135
HPRD ID		10869	07303
Ensembl ID		ENSG00000023892	ENSG00000128283
Uniprot IDs		Q9H4E7	Q00587
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Regulation Of Signal Transduction Axon Guidance Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Morphogenesis Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Projection Organization Response To External Stimulus Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axonogenesis Positive Regulation Of Immune System Process Positive Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Axon Development Regulation Of Cell Projection Assembly Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Positive Regulation Of Cellular Component Biogenesis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Differentiation Neuron Projection Morphogenesis Positive Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Signal Transduction Cell Differentiation Innate Immune Response Regulation Of Cell-substrate Adhesion Neuron Projection Development Response To Stress Regulation Of Immune System Process Regulation Of Lipid Kinase Activity Cell Migration	Regulation Of Signal Transduction Regulation Of Signaling Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Establishment Of Protein Localization Substantia Nigra Development Regulation Of Intracellular Protein Transport Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Localization Regulation Of Filopodium Assembly Neural Nucleus Development Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction T Cell Costimulation Regulation Of Cellular Localization Midbrain Development Regulation Of Intracellular Transport Cytoskeleton Organization Regulation Of Cell Activation Regulation Of Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Cell Projection Assembly Positive Regulation Of JNK Cascade Defense Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Actin Filament Branching Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Submandibular Salivary Gland Formation Positive Regulation Of Cellular Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Protein Transport Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Shape Regulation Of JNK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transport Establishment Of Golgi Localization Phosphatidylserine Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Metalloenzyme Activity Organ Development
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