PLSCR1 and ATN1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLSCR1	ATN1
Description		phospholipid scramblase 1	atrophin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Hydrolase Activity SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Phosphatidylserine Biosynthetic Process Lipid Transport Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Negative Regulation Of Transcription By RNA Polymerase II Cell Killing Spermatogenesis Central Nervous System Development Determination Of Adult Lifespan Male Gonad Development Post-embryonic Development Cell Migration Maintenance Of Cell Polarity Response To Food Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Neuron Apoptotic Process
Pathways			Regulation of PTEN gene transcription
Drugs
Diseases			Dentatorubropallidoluysian atrophy (DRPLA)
GWAS		Gut microbiota (beta diversity) ( 27723756)	Refractive error ( 32231278)
Interacting Genes		132 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MDK MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PPDPF PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG THBS1 TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764	126 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CHRD CPAP CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 FXR1 FXR2 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SAXO4 SH3RF1 SHANK3 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 TSC1 USP2 USP54 VIM WDR5 WWP1 WWP2 YAP1 ZMYND8 ZNF503 ZSWIM8
Entrez ID		5359	1822
HPRD ID		08855	06311
Ensembl ID		ENSG00000188313	ENSG00000111676
Uniprot IDs		C9J7K9 O15162	P54259 Q86V38
PDB IDs		1Y2A
Enriched GO Terms of Interacting Partners?		Enzyme Binding Ephrin Receptor Binding Protein Binding Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Keratin Filament Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Intermediate Filament Response To Growth Factor Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Helper T Cell Diapedesis Shc-EGFR Complex Positive Regulation Of Cell-substrate Adhesion Regulation Of Superoxide Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Response To Lipid Hair Cycle Apoptotic Process Regulation Of Focal Adhesion Assembly Regulation Of MAPK Cascade Cerebellar Neuron Development Regulation Of Apoptotic Process Protein Tyrosine Kinase Activator Activity Cellular Response To Lipid Morphogenesis Of A Branching Structure ERBB Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Cell-substrate Junction Organization Gland Development Regulation Of RNA Biosynthetic Process Programmed Cell Death Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding System Development Regulation Of Cell Population Proliferation Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Regulation Of Cell-matrix Adhesion Positive Regulation Of Superoxide Anion Generation Central Nervous System Neuron Development	Protein Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Developmental Process Extracellular Matrix Structural Constituent Positive Regulation Of Metabolic Process Regulation Of Gene Expression Calcium Ion Binding Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Transcription Corepressor Activity Regulation Of Protein Stability Elastic Fiber Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway System Development Apoptotic Process DNA-binding Transcription Factor Binding Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Programmed Cell Death Cell Death Histone H3 Acetyltransferase Activity Regulation Of Cell Population Proliferation Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Projection Organization Signal Transduction Positive Regulation Of RNA Metabolic Process
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