MYO6 and DAB2

Number of citations of the paper that reports this interaction (PMID 11967127)
69

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		MYO6	DAB2
Gene Name		myosin VI	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Hypertension ( 21626137)	Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		4646	1601
HPRD ID		02985	03139
Ensembl ID		ENSG00000196586	ENSG00000153071
Uniprot IDs		Q9UM54	B2RAW0 P98082
PDB IDs			2LSW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?