MYO6 and RNF11

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		MYO6	RNF11
Gene Name		myosin VI	ring finger protein 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Early Endosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Hypertension ( 21626137)	Ventricular conduction ( 21076409)
Protein-Protein Interactions		17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2	68 interactors: AKT1 ANKRD13A APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP STAMBPL1 TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		4646	26994
HPRD ID		02985	09955
Ensembl ID		ENSG00000196586	ENSG00000123091
Uniprot IDs		Q9UM54	Q9Y3C5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Protein Modification Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Negative Regulation Of Signaling Toll-like Receptor 4 Signaling Pathway Protein K63-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Intracellular Transport Cellular Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Intracellular Protein Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Innate Immune Response Cellular Response To Stimulus
Tagcloud ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Difference) ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Intersection) ?