MYO6 and SEPTIN9

Number of citations of the paper that reports this interaction (PubMedID 30975701)
66

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MYO6	SEPTIN9
Description		myosin VI	septin 9
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Septin Ring Actin Cytoskeleton Microtubule Cytoskeleton Septin Complex Cell Division Site Intercellular Bridge Perinuclear Region Of Cytoplasm Non-motile Cilium
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion	Intracellular Protein Localization Actin Cytoskeleton Organization Septin Cytoskeleton Organization Cell Division Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly
Pathways		Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases		Deafness, autosomal recessive Deafness, autosomal dominant	Hereditary neuralgic amyotrophy (HNA); Hereditary brachial plexus neuropathy
GWAS		Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2	21 interacting genes: APP CEBPA HIF1A HNRNPD HSF2BP IKBKG LINC00839 LINC01554 MYO1C MYO6 NEDD4 PIN1 PLK1 PTPRF RAB10 SEPTIN1 SEPTIN11 SEPTIN2 SEPTIN6 SEPTIN7 STK11
Entrez ID		4646	10801
HPRD ID		02985	10360
Ensembl ID		ENSG00000196586	ENSG00000184640
Uniprot IDs		A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54	A0A0S2Z5A5 Q9UHD8
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41	4YQF 5CYO 5CYP
Enriched GO Terms of Interacting Partners?		Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization	Septin Ring Septin Complex Cell Division Site Cytoskeleton-dependent Cytokinesis Midbody Sperm Annulus Positive Regulation Of Catabolic Process Microtubule Cytoskeleton GTPase Activity Intracellular Protein Localization Molecular Adaptor Activity Positive Regulation Of Protein Metabolic Process GTP Binding Phosphothreonine Residue Binding Cellular Response To Stress Nucleotide Binding Cell Division Organelle Localization Phosphoserine Residue Binding Unconventional Myosin Complex Cytoskeletal Motor Activity Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus Cleavage Furrow Response To Metal Ion Chromosome, Centromeric Region Kinetochore Cell Cortex Cell Projection Regulation Of Protein Localization Regulation Of Protein Catabolic Process Anoikis Positive Regulation Of Proteolysis Reproductive Process Positive Regulation Of Protein Catabolic Process Motile Cilium Intracellular Signal Transduction Protein Domain Specific Binding Stress Fiber Spindle Cellular Developmental Process Cytoplasm Cell Projection Organization Protein-containing Complex Spermatogenesis Male Gamete Generation Establishment Of Localization In Cell Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Organelle Localization DNA Damage Response
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