MYO6 and LRCH3

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MYO6	LRCH3
Description		myosin VI	leucine rich repeats and calponin homology domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion	Septin Cytoskeleton Organization
Pathways		Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases		Deafness, autosomal recessive Deafness, autosomal dominant
GWAS		Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2	4 interacting genes: DGCR6L DNAAF11 MYO6 YWHAG
Entrez ID		4646	84859
HPRD ID		02985	14308
Ensembl ID		ENSG00000196586	ENSG00000186001
Uniprot IDs		A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54	B4DU23 Q96II8
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41
Enriched GO Terms of Interacting Partners?		Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization
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