OXTR and GPRASP1

Number of citations of the paper that reports this interaction (PMID 15452121)
38

Data Source:
HPRD (in vitro)

		OXTR	GPRASP1
Gene Name		oxytocin receptor	G protein-coupled receptor associated sorting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Adherens Junction Apical Plasma Membrane	Cytoplasm
	Molecular Function	Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding	Protein Binding
	Biological Process	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Response To Peptide	Endosome To Lysosome Transport G-protein Coupled Receptor Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Oxytocin Carbetocin
Diseases
GWAS		Depression and alcohol dependence ( 22064162)
Protein-Protein Interactions		4 interactors: ARRB2 AVP GPRASP1 OXT	47 interactors: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1
Entrez ID		5021	9737
HPRD ID		01328	02333
Ensembl ID		ENSG00000180914	ENSG00000198932
Uniprot IDs		B2R9L7 P30559	Q5JY77
PDB IDs
Enriched GO Terms of Interacting Partners?		Maternal Aggressive Behavior Hyperosmotic Salinity Response Aggressive Behavior Positive Regulation Of Ion Transport Regulation Of Female Receptivity Maternal Behavior Negative Regulation Of Release Of Cytochrome C From Mitochondria Female Mating Behavior Grooming Behavior Regulation Of Renal Sodium Excretion Copulation Hyperosmotic Response Regulation Of Excretion Negative Regulation Of Mitochondrion Organization Mating Behavior Response To Salt Stress Positive Regulation Of Blood Pressure Social Behavior Single-organism Behavior Mating Regulation Of Neurological System Process Regulation Of Body Fluid Levels Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Osmotic Stress Regulation Of Mitochondrion Organization Renal System Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transport Positive Regulation Of Synaptic Transmission Multicellular Organismal Reproductive Process Positive Regulation Of Hindgut Contraction Multicellular Organism Reproduction Regulation Of Anion Transport Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Hindgut Contraction Reproduction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis	G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Cytosolic Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Response To Stimulus Cellular Metal Ion Homeostasis Cell-cell Signaling Positive Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Signaling Signal Transduction Metal Ion Homeostasis Cell Communication Blood Circulation Cellular Chemical Homeostasis Ion Homeostasis Response To Stimulus Neuropeptide Signaling Pathway Regulation Of Muscle Contraction G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Homeostasis Chemical Homeostasis Regulation Of Blood Pressure Tachykinin Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Opioid Receptor Signaling Pathway Regulation Of Vasoconstriction Positive Regulation Of Uterine Smooth Muscle Contraction Neurological System Process Homeostatic Process Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Blood Pressure Behavior Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of CAMP Metabolic Process Response To Abiotic Stimulus Regulation Of Adenylate Cyclase Activity
Tagcloud ?		accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocin oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Difference) ?		accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocin oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Intersection) ?