GPRASP1 and OPRD1

Number of citations of the paper that reports this interaction (PubMedID 12142540)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down, affinity chromatography technology)

		GPRASP1	OPRD1
Description		G protein-coupled receptor associated sorting protein 1	opioid receptor delta 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Membrane Synaptic Vesicle Membrane Vesicle Dendrite Membrane Presynaptic Membrane Neuron Projection Axon Terminus Postsynaptic Membrane Spine Apparatus Postsynaptic Density Membrane Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Neuropeptide Binding
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Response To Ethanol Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS			Tourette syndrome ( 30818990)
Interacting Genes		48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237
Entrez ID		9737	4985
HPRD ID		02333	01308
Ensembl ID		ENSG00000198932	ENSG00000116329
Uniprot IDs		Q5JY77	P41143
PDB IDs			4N6H 4RWA 4RWD 6PT2 6PT3 8F7S 8Y45
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade	G Protein-coupled Receptor Binding Guanyl Nucleotide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Adaptation Of Signaling Pathway Negative Regulation Of Secretion Plasma Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Acetylcholine Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Protein Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Protein Secretion G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Peptide Hormone Secretion System Process Regulation Of Superoxide Metabolic Process Enzyme Binding Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity
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