OXTR and EMC10

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		OXTR	EMC10
Name		oxytocin receptor	ER membrane protein complex subunit 10
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex
	Molecular Function	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity	Membrane Insertase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin System Process Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Female Pregnancy Lactation Cellular Response To Hormone Stimulus Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Maternal Process Involved In Parturition Regulation Of Biological Quality Positive Regulation Of Cold-induced Thermogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Vasopressin-like receptors G alpha (q) signalling events	None
Drugs		Vasopressin Oxytocin Carbetocin Atosiban Relcovaptan	None
GWAS		Caudate activity during reward ( 28927378 ) Chronotype ( 30696823 ) Depression and alcohol dependence ( 22064162 ) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598 ) Morning person ( 30696823 )	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 )
Interacting Genes		18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3	3 interacting genes: CCR2 OXTR SMO
Entrez ID		5021	284361
HPRD ID		01328	14153
Ensembl ID		ENSG00000180914	ENSG00000161671
Uniprot IDs		B2R9L7 P30559	Q5UCC4
PDB IDs		6TPK 7QVM 7RYC	6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
GO Terms Enriched among Interactors		Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Maternal Behavior Grooming Behavior Parental Behavior Receptor Catabolic Process Mating Behavior Neuronal Dense Core Vesicle Positive Regulation Of Fatty Acid Biosynthetic Process Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Response To Electrical Stimulus Reproductive Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Fatty Acid Metabolic Process Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding Receptor Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Tarsal Gland Development Uterine Gland Development	G Protein-coupled Receptor Activity Homeostasis Of Number Of Cells Within A Tissue Oxytocin Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Cold-induced Thermogenesis Tissue Homeostasis Anatomical Structure Homeostasis Homeostasis Of Number Of Cells Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Contact Inhibition Pancreas Morphogenesis Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Detection Of Cell Density Response To Inositol CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Maternal Process Involved In Parturition Regulation Of Systemic Arterial Blood Pressure By Vasopressin Cerebellar Cortex Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Hair Follicle Development Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Multicellular Organismal Process Neutrophil Clearance Vasopressin Receptor Activity Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Spinal Cord Dorsal/ventral Patterning Midgut Development Patched Binding Cell Surface Receptor Signaling Pathway Determination Of Left/right Asymmetry In Lateral Mesoderm Forebrain Morphogenesis Regulation Of Heart Morphogenesis CAMP-dependent Protein Kinase Inhibitor Activity 9+0 Non-motile Cilium