OXTR and MVB12A

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		OXTR	MVB12A
Name		oxytocin receptor	multivesicular body subunit 12A
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	ESCRT I Complex Nucleus Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Endosome Membrane Membrane Late Endosome Membrane Vesicle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin System Process Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Female Pregnancy Lactation Cellular Response To Hormone Stimulus Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Maternal Process Involved In Parturition Regulation Of Biological Quality Positive Regulation Of Cold-induced Thermogenesis	Protein Transport Macroautophagy Virus Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Receptor Catabolic Process Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Membrane Fission
Pathways		Vasopressin-like receptors G alpha (q) signalling events	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs		Vasopressin Oxytocin Carbetocin Atosiban Relcovaptan	None
GWAS		Caudate activity during reward ( 28927378 ) Chronotype ( 30696823 ) Depression and alcohol dependence ( 22064162 ) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598 ) Morning person ( 30696823 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3	8 interacting genes: APP CD2AP HSF2BP OXTR PPP1R27 SH3KBP1 SNCA UBC
Entrez ID		5021	93343
HPRD ID		01328	14298
Ensembl ID		ENSG00000180914	ENSG00000141971
Uniprot IDs		B2R9L7 P30559	Q96EY5
PDB IDs		6TPK 7QVM 7RYC	6VME
GO Terms Enriched among Interactors		Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Maternal Behavior Grooming Behavior Parental Behavior Receptor Catabolic Process Mating Behavior Neuronal Dense Core Vesicle Positive Regulation Of Fatty Acid Biosynthetic Process Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Response To Electrical Stimulus Reproductive Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Fatty Acid Metabolic Process Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding Receptor Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Tarsal Gland Development Uterine Gland Development	Collateral Sprouting Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Nuclear Envelope Lumen Cellular Response To Copper Ion Supramolecular Fiber Organization Regulation Of Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Response To Copper Ion Leukocyte Activation Involved In Inflammatory Response Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Synapse Organization Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Apoptotic Process Growth Cone Lamellipodium Neuron Projection Regulation Of Response To Calcium Ion Macrophage Activation Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Oxytocin Receptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Programmed Cell Death Cell Death Adult Locomotory Behavior Response To Interleukin-1 Axon Acetylcholine Receptor Activator Activity Protein Tetramerization Endocytosis Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization PTB Domain Binding