GPRASP1 and CALCR

Number of citations of the paper that reports this interaction (PubMedID 15086532)
0

Data Source:
BioGRID (pull down)

		GPRASP1	CALCR
Description		G protein-coupled receptor associated sorting protein 1	calcitonin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Acrosomal Vesicle Plasma Membrane Cilium Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3
	Molecular Function	Protein Binding	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Calcitonin Binding Calcitonin Family Receptor Activity Amylin Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Ossification Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Negative Regulation Of Ossification Osteoclast Differentiation Regulation Of MRNA Stability Positive Regulation Of Calcium-mediated Signaling Response To Glucocorticoid Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Response To Amyloid-beta Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways			G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs			Salmon calcitonin Pramlintide
Diseases
GWAS			A body shape index ( 34021172) Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 25760438 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Cutaneous leishmaniasis ( 32830257) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Type 2 diabetes ( 32499647) Weight ( 28552196)
Interacting Genes		48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1
Entrez ID		9737	799
HPRD ID		02333	00239
Ensembl ID		ENSG00000198932	ENSG00000004948
Uniprot IDs		Q5JY77	A0A0A0MSQ7 P30988
PDB IDs			5II0 5UZ7 6NIY 6PFO 6PGQ 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 8F0J 8F0K 8F2A 8F2B 9AUC
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade	Amylin Receptor Activity Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Protein Activation Cascade Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Vesicle-mediated Transport Protein Localization To Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Protein Localization To Cell Periphery Calcium Ion Transport Protein Sequestering Activity Cell Surface G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Sperm Midpiece Sarcomere Regulation Of Action Potential Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Protein Maturation Cellular Localization Protein Localization To Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Calcitonin Gene-related Peptide Binding Coreceptor Activity Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Receptor Internalization G Protein-coupled Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Brown Fat Cell Proliferation Amphisome Positive Regulation Of Protein Localization To Membrane G Protein-coupled Receptor Catabolic Process CGRP Receptor Complex Amyloid-beta Binding Amylin Receptor Complex 3 Signal Transduction Endocytosis
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