GPRASP1 and TACR1

Number of citations of the paper that reports this interaction (PubMedID 15452121)
0

Data Source:
HPRD (in vitro)

		GPRASP1	TACR1
Description		G protein-coupled receptor associated sorting protein 1	tachykinin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Cell Surface Membrane Dendrite Sperm Flagellum Cell Body Postsynaptic Membrane Sperm Head Cell Periphery Sperm Midpiece
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Aggressive Behavior Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Learning Or Memory Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Hormone Secretion Response To Pain Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS			Bipolar disorder x sex interaction ( 34099189) Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		9737	6869
HPRD ID		02333	01208
Ensembl ID		ENSG00000198932	ENSG00000115353
Uniprot IDs		Q5JY77	P25103
PDB IDs			2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP 7P00 7P02 7RMG 7RMH 7RMI 8U26
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade	Tachykinin Receptor Signaling Pathway Substance K Receptor Binding Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Positive Regulation Of Sensory Perception Of Pain Regulation Of Microtubule-based Movement Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Reproductive Process Regulation Of Microtubule-based Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway G Protein-coupled Receptor Catabolic Process Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Motility Positive Regulation Of Corticosterone Secretion Protein Localization To Nuclear Inner Membrane Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Locomotion Detection Of Stimulus Involved In Sensory Perception Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Response To Temperature Stimulus Regulation Of Corticosterone Secretion G Protein-coupled Receptor Kinase Activity Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Action Potential Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Detection Of Stimulus Antifungal Humoral Response Nuclear Membrane Negative Regulation Of Heart Rate Protein Localization To Nuclear Envelope Response To Yeast Regulation Of Cell Motility
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