GPRASP1 and HTR7

Number of citations of the paper that reports this interaction (PubMedID 15086532)
0

Data Source:
BioGRID (pull down)

		GPRASP1	HTR7
Description		G protein-coupled receptor associated sorting protein 1	5-hydroxytryptamine receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Plasma Membrane Cilium Membrane Dendrite Trans-Golgi Network Membrane Synapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Circadian Rhythm Blood Circulation Vasoconstriction G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Serotonin receptors G alpha (s) signalling events
Drugs			Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Clozapine Loxapine Cyproheptadine Imipramine Chlorpromazine Haloperidol Amoxapine Lisuride Paroxetine Risperidone Epinastine Cyclobenzaprine Maprotiline Dopamine Ergoloid mesylate Bromocriptine Quetiapine Aripiprazole Chlorprothixene Paliperidone Iloperidone Lofexidine Mianserin Asenapine Amisulpride Lurasidone Vortioxetine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine SB-269970 Aripiprazole lauroxil
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Midgestational total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	2 interacting genes: GPRASP1 GPRASP2
Entrez ID		9737	3363
HPRD ID		02333	01639
Ensembl ID		ENSG00000198932	ENSG00000148680
Uniprot IDs		Q5JY77	P34969
PDB IDs			7XTC
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade	G Protein-coupled Receptor Catabolic Process Receptor Catabolic Process Hematopoietic Stem Cell Homeostasis
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